A5086204029- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Digestive system and related health
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Amino Acid Enzymes and Metabolism
- Immune Response and Inflammation
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Metabolism and Genetic Disorders
- Colorectal Cancer Treatments and Studies
- Cellular Mechanics and Interactions
- Lung Cancer Diagnosis and Treatment
Delta (Denmark)
2024
Takeda (Denmark)
2023-2024
McGill University
2009-2014
McGill University Health Centre
2009-2012
Université de Sherbrooke
2002-2009
Canadian Institutes of Health Research
2002-2006
The Warburg effect is a tumorigenic metabolic adaptation process characterized by augmented aerobic glycolysis, which enhances cellular bioenergetics. In normal cells, energy homeostasis controlled AMPK; however, its role in cancer not understood, as both AMPK-dependent tumor-promoting and -inhibiting functions were reported. Upon stress, levels are maintained increased mitochondrial biogenesis transcriptional coactivator PGC-1α HIF, respectively. normoxia, AMPK induces PGC-1α, but how HIF...
As for other mRNA measurement methods, quantitative RT-PCR results need to be normalized relative stably expressed genes. Widely used normalizing genes include beta-actin and glyceraldehyde-3-phosphate dehydrogenase. It has, however, become clear that these can display modulated patterns of expression across tissue types during complex cellular processes such as cell differentiation cancer progression. Our objective was set the basis identifying displayed stable enterocytic between healthy...
The methionyl-tRNA synthetase (MARS) mutation is a very rare cause of congenital pulmonary alveolar proteinosis. We report 6-month-old boy born with symmetrical intrauterine growth retardation presented unexplained persistent tachypnea and hypoxemia associated severe failure to thrive, anemia, hypoalbuminemia hepatomegaly. Detailed investigations including computed tomography chest scan, bronchoscopy bronchoalveolar lavage revealed Whole exome sequencing identified homozygous novel variant...
Acute lung injury during bacterial infection is associated with neutrophilic inflammation, epithelial cell apoptosis, and disruption of the alveolar-capillary barrier. TLR4 required for in animals exposed to LPS initiates proinflammatory responses part via transcription factor NF-κB. Ligation also a proapoptotic response by activating IFN-β STAT1-dependent genes. We recently demonstrated that mammalian target rapamycin (mTOR), key controller growth survival, can physically interact STAT1...
We have shown previously that human intestinal epithelial cell survival and anoikis are distinctively regulated according to the state of differentiation. Here we analyzed roles protein kinase B/Akt isoforms in such differentiation distinctions. Anoikis was induced undifferentiated differentiated enterocytes by inhibition focal adhesion (Fak; pharmacologic or overexpression dominant-negative mutants) beta1 integrins (antibody blocking) maintaining cells suspension. Expression/activation...
Abstract Background Integrins are known to be important contributors cancer progression. We have previously shown that the integrin β4 subunit is up-regulated in primary colon cancer. Its partner, α6 subunit, exists as two different mRNA splice variants, α6A and α6B, differ their cytoplasmic domains but evidence for distinct biological functions of these variants still lacking. Methods In this work, we first analyzed expression α6B at protein transcript levels normal human colonic cells well...
The integrin α6 subunit exists as two different variants, termed α6A and α6B. These variants have been shown to harbor potentially distinct biochemical properties but little is known about their cellular function. aim of this work was characterize the expression B in relation cell proliferation differentiation human small intestinal epithelium. results showed patterns for along crypt–villus axis. Indeed, proliferative cells crypt were found predominantly express α6A, while differentiated...
Background Real-world clinical outcomes of anaplastic lymphoma kinase positive (ALK+) non-small cell lung cancer (NSCLC) patients vary. This study aimed to investigate the treatment and all ALK+ NSCLC in Denmark period 2011–2018, regardless disease stage.
Aim: The main purpose of the present study was to investigate labor market affiliation ALK+ NSCLC patients in long-term treatment as well overall survival and incidence/prevalence. Materials & methods: Nationwide retrospective all with Denmark diagnosed between 2012 2018. Results: During period had a median 44.0 months 7.8-fold increase disease prevalence. Six prior diagnosis, 81% ≤60 years age were employed. At end 18-month follow-up period, 36% Conclusion: have prolonged following but...