A5076703529- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Biomarkers in Disease Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Renal and related cancers
- Reproductive System and Pregnancy
- Asthma and respiratory diseases
- Genetic and Kidney Cyst Diseases
- Congenital Diaphragmatic Hernia Studies
- Inhalation and Respiratory Drug Delivery
- Pregnancy and preeclampsia studies
Sichuan University
2022-2025
West China Second University Hospital of Sichuan University
2022-2025
Fudan University
2022-2025
The lack of accurate understanding cellular physiology and pathophysiology during the WOI constitutes major obstacle to correct diagnosis treatment for patients with recurrent implantation failure (RIF). role cilia as one key organelles in endometrial epithelium has been poorly understood embryo implantation. In this study, morphological molecular changes regulated by hormones were demonstrated epithelial organoid models. Multi-omics studies revealed highly relevant cilia-related activities...
The nasal epithelium, as part of a continuous and integrated airway provides more accessible sample source than the bronchial epithelium. However, similarities differences in gene expression patterns immune responses between these two sites have not been extensively studied. Four lines matched epithelial cells obtained from four patients were embedded Matrigel cultured thechemically defined medium to generate patient-derived organoids (NO) (BO). Histologic examination organoid tissue...
Primary cilia dyskinesia (PCD) is a rare genetic disease caused by ciliary structural or functional defects. It causes severe outcomes in patients, including recurrent upper and lower airway infections, progressive lung failure, randomization of heterotaxy. To date, although 50 genes have been shown to be responsible for PCD, the etiology remains elusive. Meanwhile, owing lack model mimicking pathogenesis that can used as drug screening platform, thereby slowing development related...
Dynein axonemal heavy chain 5 (DNAH5) is the most mutated gene in primary ciliary dyskinesia (PCD), leading to abnormal cilia ultrastructure and function. Few studies have revealed genetic characteristics pathogenetic mechanisms of PCD caused by DNAH5 mutation. Here, we established a child airway organoid directly from bronchoscopic biopsy patient with The motile were observed could be stably maintained for an extended time. We further found function decreased immune response mutation...