A5101113905- Immunotherapy and Immune Responses
- earthquake and tectonic studies
- Seismic Imaging and Inversion Techniques
- Seismic Waves and Analysis
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Seismology and Earthquake Studies
- Cryospheric studies and observations
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- 3D Printing in Biomedical Research
- Chemokine receptors and signaling
- ATP Synthase and ATPases Research
- Climate change and permafrost
- CAR-T cell therapy research
- Dietary Effects on Health
University of Science and Technology of China
2023-2025
Shanghai University
2021-2024
Shuguang Hospital
2021-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Peking University
2019
Tumor growth and progression is characteristically associated with the synergistic effects of uncontrolled cellular proliferation cell survival under stress. Pyruvate kinase M2 (PKM2) contributes to both these effects. However, specific mechanism by which PKM2 promotes or stress in different nutritional environments unclear. We show that succinylation mediated mitochondrial translocation glucose starvation plays a role switching machinery from mode vice versa. Mitochondrial inhibits...
Summary The Tibetan Plateau, a critical region influencing both local and global atmospheric circulation, climate dynamics, hydrology, terrestrial ecosystems, is undergoing climate-driven changes, including glacial retreat, permafrost thaw, groundwater changes. Despite its importance, implementing continuous systematic observations have been challenging due to the area’s high altitude extreme conditions. In this context, seismic interferometry emerges as cost-effective method for monitoring...
ABSTRACT Continuous monitoring of seismogenic faults can advance our understanding the evolution process, holding important keys for forecasting future earthquakes. We report here seismic velocity variations around Anninghe fault zone in southwest China based on interferometry techniques. observed that tidal forces significantly impact changes within fracture zone, inducing periodic diurnal, semidiurnal and monthly scales. Moreover, response to Earth tides is notably more pronounced compared...
Energy metabolism reprogramming has been implicated in tumorigenesis and development. Key enzyme Aldolase A (ALDOA) shown to be highly expressed involved various kinds of cancers including hepatocellular carcinoma. In this study, we found that ALDOA was clinical intrahepatic cholangiocarcinoma (ICC) tissues, its high expression negatively correlated with overall survival (OS) recurrence-free (RFS) ICC patients. Knockdown significantly inhibited the proliferation migration both vitro vivo,...
Abstract Osteopontin (Opn) depletion can improve septic outcomes, but the underlying mechanism remains unknown. In this study, we demonstrated that nonhematopoietic not hematopoietic Opn improved outcomes. When compared with wild type mice, cohoused Opn−/− mice displayed enhanced production of antibacterial peptides (AMPs), decreased bacterial loads, and a distinct composition gut microbiota. Fecal microbiota transplantation OPN neutralization assay showed could reduce loads inflammation. By...
Triple negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and limited treatment options. Conventional therapies often lead to systemic relapse, immunotherapy faces challenges such as insufficient immune activation lack of tumor specificity. To overcome these limitations, we propose a novel strategy using engineered oncolytic vaccinia virus (VV) combined chimeric antigen receptor (CAR) T-cell therapy treat TNBC. This designed increase specificity through the expression...
Objective To evaluate the expression of C‐C motif chemokine ligand 5 (CCL5) in hepatocellular carcinoma (HCC) and to explore its role regulating immune microenvironment related mechanism tumor immunity. Methods The mRNA level CCL5 HCC adjacent non‐cancerous tissues was measured by quantitative polymerase chain reaction protein examined immunohistochemistry. Serum an enzyme‐linked immunosorbent assay (ELISA). C57BL/6 wild‐type (WT) Ccl 5‐knockout ( Ccl5 −/− ) mice were utilized conduct...