A5026115671- Synthesis and biological activity
- Fatty Acid Research and Health
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Amoebic Infections and Treatments
- Cancer therapeutics and mechanisms
- Peroxisome Proliferator-Activated Receptors
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Machine Learning in Materials Science
- Cytokine Signaling Pathways and Interactions
- HIV-related health complications and treatments
- Cancer Cells and Metastasis
- HIV Research and Treatment
- Natural Products and Biological Research
- Topic Modeling
- RNA Interference and Gene Delivery
- Vitamin C and Antioxidants Research
- Quinazolinone synthesis and applications
- Herpesvirus Infections and Treatments
University of Agricultural Sciences, Bangalore
2024-2025
Jawaharlal Nehru University
2025
University of Bristol
2000
Nizam's Institute of Medical Sciences
1988
Abstract The interrelations between linoleic acid (LA) metabolites and fish oil fatty acids were studied. Sprague‐Dawley rats (200–220 g) fed a fat‐free semisynthetic diet supplemented with 10% (by weight) of different combinations evening primrose (EPO), rich source LA γ‐linolenic acid, polepa (POL), marine in eicosapentaenoic (EPA) docosahexaenoic (DHA) acids. supplement as follows: 9% EPO‐1% POL, 8% EPO‐2% 7% EPO‐3% 6% EPO‐4% POL 5% EPO‐5% POL. After two weeks on the respective diets,...
Generative artificial intelligence (AI) has emerged as a disruptive paradigm in molecular science, enabling algorithmic navigation and construction of chemical proteomic spaces through data-driven modeling. This review systematically delineates the theoretical underpinnings, architectures, translational applications deep generative models—including variational autoencoders (VAEs), adversarial networks (GANs), autoregressive transformers, score-based denoising diffusion...
Head-and-neck squamous cell carcinoma (HNSCC) is a complex malignancy characterized by highly heterogeneous tumor microenvironment (TME) that influences progression, metastasis, and therapeutic resistance. Despite significant advancements in understanding HNSCC at the molecular level, comprehensive analyses of TME-related research within this domain remain limited. Hence, study presents bibliometric analysis TME HNSCC, synthesizing data on publication trends, citation patterns, collaborative...
Abstract The phylloplane of edible and culinary plants harbours diverse microbial communities, including lactic acid bacteria (LAB), which remain underexplored for their probiotic potential. This study aimed to isolate LAB from the leaf surfaces eight plant species: Sauropus androgynus, Piper betle, Centella asiatica, Artocarpus heterophyllus, Pandanus amaryllifolius, Musa paradisiaca, Curcuma longa , Ricinus communis . isolates were characterized essential traits, tolerance acid, bile...
Background: The growing demand for sustainable and health-conscious foods has led to innovative uses of fruit by-products. Dragon peel, often discarded, is high in fiber antioxidants, while mango pulp enhances taste nutritional value. This study focused on developing a fiber-rich, leather, assessing its physicochemical, nutritional, sensory properties evaluate potential commercialization. Methods: Two leather formulations were prepared: one with spices without. Their physicochemical...
The FLT3 protein is a well-established therapeutic target in the treatment of Acute Myeloid Leukemia (AML), with its inhibition playing crucial role disease management. In this study, we identify and propose novel inhibitor that demonstrates superior binding affinity, stability, pharmacokinetic properties compared to currently available inhibitors. We initially characterized interactions known inhibitors through molecular docking then strategically modified functional groups enhance optimize...
ABSTRACT FLT3 mutations, observed in approximately 30-35% of Acute Myeloid Leukemia (AML) cases, drive leukemic proliferation and survival pathways, presenting a significant challenge clinical management. To address this therapeutic need, we employed comprehensive computational approach integrating pharmacophore screening, molecular docking, ADMET analysis, dynamics simulations to identify potent inhibitors targeting FLT3. Utilizing ligand-based models generated from experimentally proven...
Circular RNA (circRNA) vaccines are emerging as a revolutionary strategy in cancer immunotherapy, offering novel mechanisms for inducing robust and durable immune responses. Unlike traditional linear mRNA vaccines, circRNAs exhibit exceptional stability, enhanced translational efficiency, resistance to exonuclease degradation, making them ideal candidates vaccine development. This review delves into the fundamental principles underlying circRNA biology, highlighting their unique structural...
ABSTRACT Mcl-1, a Bcl-2 family protein, is key regulator of apoptosis and often overexpressed in cancers such as lung, breast, pancreatic, cervical, ovarian cancers, leukemia, lymphoma. Its role inhibiting enables tumor cells to evade cell death contributes drug resistance. Targeting Mcl-1 crucial inducing overcoming resistance therapies that target other anti-apoptotic proteins, making it prominent for anticancer development across multiple malignancies. So, our study aimed discover potent...
ABSTRACT Background Mutations in isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are prevalent drivers of acute myeloid leukemia (AML). While targeted therapies exist, resistance can emerge. This study explored the potential natural products to identify novel dual IDH inhibitors. Methods In-silico screening COCONUT database was performed using Lipinski’s Rule Five. Pharmacophore modelling identified crucial features for binding. Docking simulations with Glide (Schrödinger) assessed binding...
ABSTRACT Aberrant DNA methylation, a hallmark of acute myeloid leukemia (AML), is catalyzed by methyltransferase 3A (DNMT3A). Approximately 20-30% AML patients harbor DNMT3A mutations, leading to disrupted methylation patterns and leukemogenesis. To identify potential therapeutic interventions, this study employed computational drug discovery. A pharmacophore model was constructed utilized screen natural product database, yielding set promising compounds. Subsequent molecular docking,...
ABSTRACT Circular RNA (circRNA) vaccines are emerging as a revolutionary strategy in cancer immunotherapy, offering novel mechanisms for inducing robust and durable immune responses. Unlike traditional linear mRNA vaccines, circRNAs exhibit exceptional stability, enhanced translational efficiency, resistance to exonuclease degradation, making them ideal candidates vaccine development. Recent studies have shown that circRNA play an important specialized role treatment. However, there...
<title>Abstract</title> The study of head and neck cancer (HNC) has been significantly enhanced by the development 3D spheroid models, which closely replicate in vivo tumor microenvironment (TME) preserving cellular heterogeneity, hypoxic regions, tumor-specific cell interactions. Traditional 2D models lack capacity to capture these critical characteristics, are essential for understanding biology therapeutic responses. This review summarizes recent advancements HNC research, with a focus on...