A5054054395- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Migraine and Headache Studies
- Spinal Dysraphism and Malformations
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Fetal and Pediatric Neurological Disorders
- Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Trigeminal Neuralgia and Treatments
- Distributed and Parallel Computing Systems
- Trace Elements in Health
- Olfactory and Sensory Function Studies
- Sympathectomy and Hyperhidrosis Treatments
- Cerebrovascular and genetic disorders
- Restless Legs Syndrome Research
- Scientific Computing and Data Management
- Heavy Metal Exposure and Toxicity
- Sleep and Wakefulness Research
General University Hospital in Prague
2024-2025
Charles University
2024-2025
Klinikum Klagenfurt
2009
Women's General Hospital
2006
This open study evaluates the effectiveness and safety of topiramate for prophylaxis chronic tension-type headache. Fifty-one patients were enrolled, whom 46 completed 24 weeks treatment with topiramate. Daily dosing was titrated from 25 mg to 100 by week 4. The primary efficacy parameter headache frequency at 13-24 compared baseline. Headache declined 23.50 +/- 5.32 days (baseline, mean, SD) 12.58 6.28 (P < 0.0001), severe headaches dropping 8.18 3.14 0.0001). average intensity dropped 6.13...
Abstract Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by the loss of muscle atonia and abnormal, often violent, movements vocalizations during REM sleep. It strongest prodromal marker for progression to synucleinopathies such as dementia with Lewy bodies (DLB) Parkinson’s disease (PD). iRBD individuals already show brain changes consistent manifest synucleinopathies, but their mechanisms remain poorly understood. The glymphatic system involved in...
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a non-invasive marker of glymphatic function that typically relies on manual region interest (ROI) placement. This study compared in treatment-naive, de novo diagnosed patients with Parkinson's disease (PD), isolated REM behavior disorder (iRBD), and healthy controls using both automatic DTI-ALPS methods. ALPS scores were analyzed bilaterally correlated clinical severity (MDS-UPDRS) nigrostriatal denervation...
Abstract Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a potential non-invasive marker of glymphatic function that typically relies on manual region interest (ROI) placement. This study compared ALPS indices in treatment-naïve, de novo diagnosed patients with Parkinson’s disease (PD), isolated REM behavior disorder (iRBD), and healthy controls using both automatic approaches to ROI selection used ALPS-index calculation. were analyzed bilaterally correlated...
Abstract Isolated REM sleep behavior (iRBD) is a male predominant parasomnia characterized by abnormal dream-enacting movements in sleep. It the prodromal manifestation most strongly associated with development of synucleinopathies, such as Parkinson’s disease or dementia Lewy bodies. While individuals iRBD exhibit significant cortical atrophy shaped distinct gene expression, sex-specific differences structural brain changes remain unknown. In this study, we investigate effect sex on and...
INTRODUCTION: Most individuals with isolated REM sleep behavior disorder (iRBD) develop dementia Lewy bodies (DLB) or Parkinson's disease (PD). Brain biomarkers predicting specific phenoconversion trajectories are lacking. METHODS: In this multicenter diffusion MRI study (261 iRBD, 177 controls), free water (FW) was measured in the nucleus basalis of Meynert (NBM) and posterior substantia nigra (SN). Among 230 iRBD patients follow-up, 64 converted (16 DLB, 38 PD). Time-to-event analyses were...
Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen iRBD; however, how begins progresses remains unclear. A multicentric cohort 1276 participants (451 polysomnography-confirmed iRBD, 142 PD probable RBD, 87 DLB, 596 controls) underwent T1-weighted MRI longitudinal clinical assessments....
The rationale for our study was to examine the prophylactic benefit of two doses amitriptyline over a 6-month observational period in patients with migraine. We aimed at evaluating whether 50 mg amitryptiline extended release more effective than 25 reducing number migraine days.Primary outcome measure reduction days time course (i.e., 3 and 6 months after patient enrolment). As secondary analyses, predictors treatment response were evaluated. Treatment defined as > or =30% =50% headache...
Abstract Striosomes and matrix are two compartments that comprise the striatum, each having its own distinct immunohistochemical properties, function, connectivity. It is currently not clear whether prodromal or early manifest Parkinson’s disease (PD) associated with any striatal striosomal abnormality. Recently, a method of parcellation using probabilistic tractography has been described validated, connectivity these to identify voxels striosome- matrix-like The goal this study was use...
Abstract Background Synucleinopathies manifest as a spectrum of disorders that vary in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) dementia with Lewy bodies. Patterns brain atrophy iRBD are already reminiscent what is later seen overt disease related to cognitive impairment, being associated the development However, how begins progresses remains unclear. Methods A multicentric cohort 1,134 participants, 538 patients synucleinopathies (451...
<title>Abstract</title> Glymphatic dysfunction can contribute to Parkinson’s disease (PD). Obstructive sleep apnea (OSA) disturbs sleep, which is necessary for its proper function, and frequent in PD. We investigated the glymphatic function de novo PD relation OSA. Fifty-four patients (mean age 58.9 ± 12.2 years) 32 controls 59.4 8.3 underwent polysomnography 3T magnetic resonance imaging of brain. Diffusion tensor along perivascular space (DTI-ALPS) was calculated using atlas-based...
Abstract Wilson disease (WD) primarily presents with hepatic and neurological symptoms. While symptoms typically precede the manifestations, copper accumulates in brain already this patient group leads to subclinical MRI abnormalities including T2 hyperintensities atrophy. This study aimed assess morphological changes mild WD. WD patients without a history of neurologic decompensated cirrhosis control participants underwent at 3T scanner high‐resolution T1‐weighted images. A volumetric...