A5052904157- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Thyroid Disorders and Treatments
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Chronic Lymphocytic Leukemia Research
- Biochemical Analysis and Sensing Techniques
- Marriage and Sexual Relationships
- Lung Cancer Diagnosis and Treatment
- Graph Labeling and Dimension Problems
- Treatment of Major Depression
- Product Development and Customization
- Maternal Mental Health During Pregnancy and Postpartum
- Diagnosis and treatment of tuberculosis
- Gastrointestinal motility and disorders
- Electroconvulsive Therapy Studies
North Shore Hospital
2024
Royal North Shore Hospital
2021-2024
Northern Sydney Local Health District
2023-2024
The University of Sydney
2023-2024
Bridge University
2012-2023
College of Charleston
2023
University of Colorado System
2023
University of Colorado Boulder
2023
New York Law School
2021-2023
New York University
2021-2023
Oxytocin binding (Bmax) was found to be higher in the ventral tegmental area (VTA) and medial preoptic (MPOA) at midparturition compared with Pregnancy Days 15-17 or Postpartum 5-7 rat dams. Pup retrieval assuming a nursing posture over pups were blocked parturient dams by infusions of an oxytocin antagonist into VTA MPOA vasopressin (V1) MPOA. These results implicate MPOA, as well parturition-associated rise these sites postpartum activation maternal behavior.
This research adopted a model of goal activation to study the mechanisms underlying interrupted task performance. The effects interruption timing, type interruption, and age on time primary resumption were explored under conditions in which attention was switched back forth between two tasks, much as when drivers shift attending road an in-vehicle task. timing interruptions had significant impact times, indicating that most costly interrupt performance is during middle However, this effect...
Objective and Method Findings from both animal human research suggest that pain sensitivity changes across the menstrual cycle; however, among humans nature of these cycle effects remains unclear. The present study used a repeated-measures design to evaluate in thermal ischemic responses during three phases cycle, midfollicular (postmenstrual), ovulatory, mid-to-late luteal (premenstrual), 11 healthy women. phase which subjects began their participation was determined randomly. Plasma levels...
Intracisternal (i.c.) injection of neurotensin (NT) to rats or mice attenuated the locomotor hyperactivity induced by d-amphetamine, methylphenidate cocaine, but not increased activity apomorphine lergotrile. The reduction methylphenidate-induced i.c. NT was due an drug metabolism because did change plasma concentrations. These actions are distinct from those dopamine receptor antagonist haloperidol, which blocked all five stimulant drugs in rats. A further difference between and...
Neurotensin (NT), administered intracisternally to mice, produced significant dose-dependent antinociception in three analgesic tests: tail immersion, hot-plate and acetic acid writhing. Naloxone (1-5 mg/kg), an opiate antagonist i.p. 20 min before NT administration, did not significantly alter NT-induced any of these tests; naloxone reverse beta-endorphin-induced antinociception. However, centrally peripherally thyrotropin-releasing hormone antagonized (but beta-endorphin-induced) Equimolar...
Summary Arsenic trioxide is an essential component of therapy for acute promyelocytic leukaemia (APL) and currently dosed on actual body weight with no upper limit. Arsenic‐induced neurotoxicity a well‐recognised complication; however, there uncertainty about its relationship to arsenic dose obesity. We conducted large multicentre retrospective study 487 patients APL treated arsenic‐based across 23 sites in Australia from 2008 2023. The primary outcome was incidence neurotoxicity, secondary...
Summary A biosocial model of the effects early adolescent testosterone levels and religiosity on males' sexual attitudes activity over a 3-year period was examined. Using panel data for approximately 100 boys who were 12·5/13·0 years old at study entry, significant additive free frequency attendance religious services demonstrated transition to first intercourse other aspects behaviour attitudes. No interactive two predictors found. Boys with higher entry never or infrequently attended most...
We examined neuroendocrine correlates of central monoamine function in patients with the generalized type social phobia compared to healthy volunteers order test hypotheses dopaminergic, noradrenergic, and/or serotonergic dysregulation this disorder. A double-blind, placebo-controlled, neuropharmacological challenge study was performed using probes for (fenfluramine), dopaminergic (levodopa), and noradrenergic (clonidine) systems. Twenty-one DSM-III-R (generalized type) 22 "never mentally...
Serum levels of luteinizing hormone (LH), follicle stimulating (FSH), prolactin, estradiol-17 beta and testosterone were determined in adult rats that treated the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles ventral prostate) tests lower serum concentrations FSH than sex-matched controls. females LH, beta....
We examined the prevalence of antimicrosomal and antithyroglobulin antibodies in psychiatric inpatients with unipolar depression (N = 218), bipolar disorder manic 51), depressed 19), mixed 26) comparison two control groups: adjustment 80) family medicine outpatients without current illness 144). A statistical analysis that controlled for age sex revealed frequency positive antibody titers not to be increased patients a diagnosis (6.9%) or (3.9%), when compared (2.5%) non-psychiatric subjects...
Neuroendocrine challenge paradigms have been used to asses serotonergic systems in depression, but limitations the specificity of many these tests noted. In this study, neuroendocrine responses acute intravenous administration serotonin (5-HT) reuptake inhibitor clomipramine were assessed depressed patients and matched control subjects.Thirty hospitalized who met DSM-III-R criteria for major 30 healthy subjects age, sex, season year time received 12.5 mg intravenously administered...
It is common to treat some diseases with more than one medication simultaneously. Since neurotransmitter system involved in alcohol-seeking behaviour, then a therapeutic approach that targets should be effective reducing alcohol intake addressing single system. To test this hypothesis, we compared the efficacy of low doses individual drugs reported reduce voluntary drinking mixture these agents at same three strains alcohol-preferring rats (P, HAD, and Fawn-Hooded). After establishment...