A5087243003- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- melanin and skin pigmentation
University of Cambridge
2023-2025
Wellcome/MRC Institute of Metabolic Science
2024
Mutations that perturb leptin-melanocortin signaling are known to cause hyperphagia and obesity, but energy expenditure has not been well studied outside rodents. We report on a common canine mutation in pro-opiomelanocortin (
Obesity is a heritable disease, but its genetic basis incompletely understood. Canine population history facilitates trait mapping. We performed canine genome-wide association study for body condition score, measure of obesity, in 241 Labrador retrievers. Using cross-species approach, we showed obesity genes are also associated with rare and common forms humans. The lead was within the gene DENN domain containing 1B (DENND1B). Each copy alternate allele ~7% greater fat. demonstrate role this...
A canine obesity epidemic mirrors that observed in humans 1–9. Despite high heritability 10–12, human is often perjoritively viewed as the consequence of poor self regulation with influence genetics on individuals’ hunger, satiety and complex eating behaviours frequently overlooked 13–17. In dogs, also blamed owners failing to control food exercise 18–20. We studied pet dogs a compelling animal model which develops spontaneously, subject similar environmental influences their counterparts...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)