A5042790552- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Retinal Imaging and Analysis
- Cardiovascular Disease and Adiposity
- Retinal Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Food Security and Health in Diverse Populations
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Nutritional Studies and Diet
- Inflammatory Biomarkers in Disease Prognosis
- Obesity and Health Practices
- Diabetes Management and Education
- Synthesis of Tetrazole Derivatives
- Poetry Analysis and Criticism
- melanin and skin pigmentation
- Ovarian cancer diagnosis and treatment
- Extracellular vesicles in disease
- Transplantation: Methods and Outcomes
- Lipoproteins and Cardiovascular Health
- Aortic Thrombus and Embolism
- Intracerebral and Subarachnoid Hemorrhage Research
Stratford University
2024
Stanford University
2024
Royal Perth Hospital
2019-2023
The University of Western Australia
2019-2023
Monash University
2021-2023
Hospital Research Foundation
2021-2022
Monash Health
2021
Toronto Metropolitan University
2021
Barrow Neurological Institute
2019-2020
St. Joseph's Hospital and Medical Center
2019
Cuffless wearable blood pressure (BP) devices may allow detailed evaluation of BP for prolonged periods, but their ability to accurately track changes is uncertain. We investigated whether a commercially available cuffless device tracks: 24-h systolic (SBP) and diastolic (DBP) compared conventional ambulatory monitoring (ABPM); antihypertensive medication-induced cuff-based home (HBPM).We fitted 41 participants (32% females, 58 ± 14 years, 80% hypertensive) with wrist-wearable (Aktiia)...
Microvascular disease and rarefaction are key pathological hallmarks of hypertension. The retina uniquely allows direct, non-invasive investigation the microvasculature. Recently developed optical coherence tomography angiography now fine retinal capillaries, which may provide a superior marker overall vascular damage. This was prospective cross-sectional study to collect capillary density data on 300 normal eyes from 150 hypertensive adults, investigate possible associations with other...
Objective: Although the detrimental effect of increased mean blood pressure (BP) is well established, role dynamic and circadian features BP less defined but may be similarly important. In this prospective analysis hypertensive patients from a tertiary hospital hypertension clinic, we investigated whether presence night-time systolic associated with more pronounced end-organ damage as assessed by measures pulse wave (PWA) velocity (PWV). Methods: A cohort 222 consecutive underwent ambulatory...
Elevated office blood pressure (BP) has previously been associated with increased levels of circulating extracellular vesicles (EVs). The present study aimed to assess the relationship between platelet derived EVs, ambulatory BP parameters, and pulse wave velocity as a marker macrovascular organ damage. A total 96 participants were included in study. Platelet-derived (pEVs) evaluated by flow cytometry (CD41+/Annexin v+). evaluation unobserved automated monitoring. Carotid-femoral (PWV) was...
A nocturnal non-dipping pattern has been associated with hypertension-mediated organ damage (HMOD), morbidity and mortality. Retinal imaging through application of modern technologies including optical coherence tomography angiography (OCT-A) can provide detailed insights into early vascular damage. In this observational study, we investigated the relationship microscopic density in retina measured OCT-A blood pressure (BP) dipping.Retinal ambulatory BP monitoring (ABPM) data prospectively...
Abstract Homocysteine is an independent risk factor for cardiovascular and cerebrovascular disease has been proposed to contribute vascular dysfunction. We sought determine in a real‐world clinical setting whether homocysteine levels were associated with hypertension mediated organ damage (HMOD) could guide treatment choices hypertension. performed cross‐sectional analysis of prospectively collected data 145 hypertensive patients referred our tertiary clinic at Royal Perth Hospital analyzed...
Hypertension is the most common chronic condition globally, contributing to an increased risk of cardiovascular disease and premature death. Despite advances in treatment options, approximately 10% patients have resistant hypertension, characterized by elevated blood pressure that does not respond treatment. The gut microbiome now increasingly recognized play a role development pathogenesis several diseases, including although exact mechanisms remain unclear.The aim present study was...
Gnanenthiran, Sonali R.; Liu, Hueiming; Tan, Isabella; Chan, Justine; Schlaich, Markus P.; Schutte, Aletta E. Author Information
Background: Positional changes in blood pressure (BP) have been shown to effects on long-term outcomes. Although a BP drop with upright posture is frequently observed, an orthostatic rise can also occur. Here, we aimed investigate whether the phenotype of hypertension associated more pronounced vascular hypertension-mediated organ damage (HMOD) and this other cardiovascular risk factors. Methods: In cohort 200 patients referred our tertiary clinic, prospectively assessed unattended seated...
OBJECTIVE We analyzed whether any change in capillary density the retinal circulation could be detected patients with hypertension prediabetic stage. RESEARCH DESIGN AND METHODS In a cross-sectional analysis, we assessed foveal (CDF) and parafoveal areas using optical coherence tomography-angiography 62 normal glucose metabolism 40 prediabetes. RESULTS The CDF was lower prediabetes than those metabolism. Moreover, found correlation between HbA1c levels for entire cohort. <6.5% (48...
Several definitions of night-time BP exist for the calculation nocturnal blood pressure (BP) based on 24-h measurements. How much these methods differ regarding resulting values, under which circumstances differences become clinically meaningful, and diary-adjusted measurements should be used preferentially remains uncertain.Data 512 recordings were analysed in three alternative night-time: 2300-0700 h, 0100-0500 measures.Mean systolic between h was 2.5 mmHg higher than 0100 0500 1.6 diary...
Abstract Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio‐ and cerebrovascular events than end‐stage renal disease. The authors explored whether retinal microvascular calibers differed the degree of impairment between standard extended optic disk may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. analyzed central arteriolar venular equivalent (CRAE, CRVE) at different zones (zone B&C) using...
Elevated circulating platelet-derived extracellular vesicles (EVs) have been reported in conditions associated with thrombotic risk. The present study aimed to assess the relationship between EV levels, cardiovascular risk stratification and vascular organ damage, as assessed by pulse wave velocity (PWV). A total of 92 patients were included analysis. Platelet evaluated flow cytometry (CD41+/Annexin v+). was determined using 2021 ESC guideline SCORE2 SCORE-OP. PWV performed a surrogate...
Elevated nocturnal blood pressure (BP) is closely associated with increased risk of cardiovascular (CV) events. Circulating extracellular vesicles (EVs) have been proposed as a potential CV biomarker and shown to correlate BP. The present study aimed assess whether reduction in BP paralleled by respective changes EVs.Fifty-five hypertensive patients (age: 57.7 ± 14.1 years) were included the study. EVs assessed at baseline 12 weeks follow-up. Interventions lower advice on life-style...
Abstract Night‐time blood pressure (BP) is an important predictor of cardiovascular outcomes. Its assessment, however, remains challenging due to limited accessibility ambulatory BP devices in many settings, costs, and other factors. We hypothesized that measured a supine position during daytime may perform similarly night‐time when modeling their association with vascular hypertension‐mediated organ damage (HMOD). Data from 165 hypertensive patients were used who as part routine clinic...
Abstract The tumor-microenvironment (TME) of the omentum plays an important role in providing a pre-metastatic niche for high-grade serous ovarian cancer (HGSC-OvCa) progression. Omentum, layer fatty adipose tissue within peritoneal cavity, is preferred primary metastatic site OvCa. Omentum well-vascularized containing wide-spread immune clusters (milky spots). Milky spots are primarily composed B cells, T macrophages, NK and dendritic cells. Previous studies from our laboratory have...
Abstract Background Exercise stress echocardiography (ESE) is often used for pre-renal transplant risk stratification. Nearly 20% of ESE may be non-diagnostic, resulting in delays to and increased healthcare cost. A simple, reliable tool predicting non-diagnostic streamline assessment. Methods Retrospective analysis 898 kidney candidates between 2013-2020 who underwent exercise pre-transplant cardiovascular assessment was performed. The cohort separated into a derivation validation set....