A5017520039- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Muscle Physiology and Disorders
- Connexins and lens biology
- Genetic Neurodegenerative Diseases
- Diversity and Career in Medicine
- Cervical Cancer and HPV Research
- Biochemical effects in animals
- Neuroscience of respiration and sleep
- Muscle metabolism and nutrition
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Dental Education, Practice, Research
- Advanced Glycation End Products research
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Biomarkers in Disease Mechanisms
- 14-3-3 protein interactions
- Medical and Biological Sciences
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
Stanford University
2022-2024
Walter Reed National Military Medical Center
2023
Creative Commons
2023
Palo Alto University
2022-2023
Stanford Health Care
2023
Sutter Health
2023
Dartmouth College
2023
Kaohsiung Veterans General Hospital
2023
California Pacific Medical Center
2023
Henry M. Jackson Foundation
2023
To analyze mortality trends in uterine cancer the United States over 50 years with an emphasis on age and race ethnicity.Data deaths from 1969 to 2018 were obtained National Center for Health Statistics. Trends examined by ethnicity after adjustment hysterectomy rate pregnancy.Uterine decreased between 1997 (from 6.03 4.00/100,000) but increased 4.00 5.02/100,000). From 2001 2018, rates 1.25-fold across all groups. In patients aged 70 or older 60-69 was sixfold threefold higher,...
The present study addressed the hypothesis that reducing mTOR, as seen in mTOR heterozygous (+/−) mice, would exaggerate changes protein synthesis and degradation observed during hindlimb immobilization well impair normal muscle regrowth recovery period. Atrophy was produced by unilateral data compared to contralateral gastrocnemius. In wild-type (WT) gradual loss of mass plateaued day 7. This response associated with a reduction basal development leucine resistance. Proteasome activity...
Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic intervention. Purinergic signaling has been shown to regulate vascular function pathological processes, including inflammation arterial myogenic reactivity, plays role ischemic outcome. requires extracellular purines; mechanism purine release from cells unclear. Pannexin1 (Panx1) channels are potentially novel expressed throughout tree...
Deptor is an mTOR binding protein that affects cell metabolism. We hypothesized knockdown (KD) of in C2C12 myocytes will increase synthesis via stimulating mTOR-S6K1 signaling. KD was achieved using lentiviral particles containing short hairpin (sh)RNA targeting the mouse mRNA sequence, and control cells were transfected with a scrambled shRNA. reduced content by 90%, which increased phosphorylation kinase substrates, 4E-BP1 S6K1, concomitantly synthesis. myoblasts both larger diameter...
Elevated NaCl concentrations of the cerebrospinal fluid increase sympathetic nerve activity (SNA) in salt-sensitive hypertension. Neurons rostral ventrolateral medulla (RVLM) play a pivotal role regulation SNA and receive mono- or polysynaptic inputs from several hypothalamic structures responsive to hypernatremia. Therefore, present study investigated contribution RVLM neurons pressor response Lateral ventricle infusion 0.15 mol/L, 0.6 1.0 mol/L (5 µL/10 minutes) produced...
Ovarian neoplasms are a heterogeneous group of tumors with varying incidence in the general population. The most common surface epithelial which include transitional cell tumors. Transitional both carcinoma and Brenner tumor. vast majority benign, often incidental findings; however, malignant (MBT) do occasionally occur. MBT present similarly to other ovarian abdominal pain bulk symptoms. On imaging, these demonstrate nonspecific findings. Microscopically, they areas conventional benign...
This case series discusses a human papilloma virus (HPV)–related neovaginal squamous cell carcinoma in transgender woman and the need for formal gynecologic screening recommendations.
Abstract Board certification is a universal ambition among graduates of American medical schools. It measure postgraduate achievement and clinical ability that leads to staff appointments, promotions, privileges, increased fees, reduced mal-practice premiums. The number physicians receiving specialty-board diplomas each year has remarkably over the past 15 years. annual mean for years 1976–1978 was 17,381 — larger than graduating class four before. board-certified in medicine, surgery,...
Advanced mixed epithelial endometrial carcinomas are rare high-grade cancers with a poor prognosis. A clear cell component infers relative chemotherapy insensitivity, likely further increased by p53 wild type status and MMR deficiency. PD-1 inhibition for deficient has been recently added to first-line adjuvant treatment in combination platinum-based chemotherapy. Information on de-escalation of alone without is sparse.
The role of mTOR in regulating muscle protein balance was assessed WT and heterozygous (+/−) mice after hindlimb immobilization recovery, with data compared to the contralateral muscle. A gradual loss mass, which plateaued by day 7, seen mice. This response associated a sustained reduction synthesis increased proteasome activity. Atrogin‐1 MuRF‐1 mRNA transiently but returned control values 7. decreased mass activity did not differ between +/− immobilization. After 10 days showed no...
•Deloyers procedure is an alternative to ileorectal anastomosis.•Deloyers can be performed after a prior partial colectomy.•Use of this may help achieve complete gross resection during cytoreductive surgery.
Es wurde ein einfaches Befundsystem häufiger mittels CT sichtbarer Veränderungen beim zerebralen Insult für eine Datenbank entwickelt. Jeder CT-Pathologie wird dreistelliger Code zugeordnet, welcher entweder einem lokalen Infarkttyp, Hauptast oder einer generalisierten Hirnveränderung entspricht. Zusätzlich werden Dichte ohne Kontrastmittel, Anfärbeverhalten, Ödem, Größe der Läsion sowie klinische Relevanz dokumentiert. In unabhängigen Auswertung von 13 als charakteriistisch erachteten...
Compelling evidence indicates increased CSF sodium concentration elevates sympathetic nerve activity (SNA) and arterial blood pressure (ABP) in salt‐sensitive hypertension. RVLM neurons project to the spinal cord regulate SNA ABP under a number of physiological challenges pathophysiological states. Therefore, we hypothesized that mediate sympathoexcitatory response sodium. Inactin‐anesthetized, male Sprague‐Dawley rats (n=5/group) were infused with 1M NaCl (5 μL/10 min) or artificial lateral...
<h3>Objectives</h3> To analyze mortality trends in uterine cancer the United States over 50 years. <h3>Methods</h3> Mortality data for from 1969–2018 were collected National Center Health Statistics. rates extracted using SEER*Stat 8.3.9. Trends (average annual percent change, AAPC) calculated with Joinpoint 4.9.0.0. Age-adjusted rate was adjusted by US 2000 standard population. hysterectomy and pregnancy 2001 to 2018. <h3>Results</h3> Uterine decreased 1969–1997 but increased 1997–2018....
We have recently shown that the alpha subunit of hemoglobin (Hbα) is found in endothelial cells (EC) resistance arteries and it closely associates with NO synthase (eNOS) to regulate nitric oxide (NO) diffusion from EC smooth muscle (SMC) after adrenergic constriction. Hypertensive mouse models significantly increased Hbα/eNOS association, whereas application a peptide (HbαX) intended disrupt interaction functionally ablate NO-scavenging decreased association. In order test this proposed...