A5101918242- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- Bacteriophages and microbial interactions
- Autoimmune Neurological Disorders and Treatments
- Ion channel regulation and function
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
University of Würzburg
2023-2025
Bangladesh Council of Scientific and Industrial Research
2021
Autoantibodies (aAbs) against glycine receptors (GlyRs) are mainly associated with the rare neurologic diseases stiff person syndrome (SPS) and progressive encephalomyelitis rigidity myoclonus (PERM). GlyR aAbs also found in other such as epilepsy. The bind to different α-subunits and, more rarely, β-subunit. So far, studies on pathogenic effects of have focused postsynaptic, heteromeric GlyRs, reporting a loss ion channel function receptor internalization upon aAb binding. We asked whether...
Neuromodulatory signaling via G protein-coupled receptors (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. The recent development of optogenetic tools to induce protein-mediated provides the promise acute cell type-specific manipulation neuromodulatory signals. However, designing deploying optogenetically functionalized GPCRs (optoXRs) with accurate specificity activity mimic endogenous vivo remains challenging. Here we optimize design optoXRs by...
This study reports the coding-complete genome sequence, with variant identifications and phylogenetic analysis, of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) P.1 (20J/501Y.V3), obtained from an oropharyngeal swab specimen female Bangladeshi patient diagnosed disease 2019 (COVID-19) no travel history.
Abstract Patients with autoantibodies (aAbs) against the contactin-associated protein-like 2 (CASPR2) suffer from a variety of clinical syndromes including neuropathic pain, in some patients even as only symptom. CASPR2 is an adhesion protein neurexin IV family and part voltage-gated potassium channel complex (VGKC) neurons dorsal root ganglia (DRG). The subsequent pathological mechanisms following binding aAbs their association pain are partially understood. mainly IgG4 subclass. Previous...
Abstract Neuromodulatory signaling via G protein-coupled receptor (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. Recent efforts have led to the development of optogenetic tools induce protein-mediated signaling, with promise acute cell type-specific manipulation neuromodulatory signals. However, designing deploying optogenetically functionalized GPCRs (optoXRs) accurate specificity activity mimic endogenous vivo remains challenging. Here we optimized...