A5033897673- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced Biosensing Techniques and Applications
- Click Chemistry and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Synthesis and characterization of novel inorganic/organometallic compounds
- Neuroscience and Neuropharmacology Research
- Synthesis and Properties of Aromatic Compounds
- Photoreceptor and optogenetics research
- bioluminescence and chemiluminescence research
- Mechanical Engineering and Vibrations Research
- Traffic and Road Safety
- Electric and Hybrid Vehicle Technologies
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Autonomous Vehicle Technology and Safety
- Vehicle Dynamics and Control Systems
- Traffic control and management
- Monoclonal and Polyclonal Antibodies Research
Max Planck Institute for Medical Research
2021-2022
Heidelberg University
2018-2021
Small-molecule fluorophores enable the observation of biomolecules in their native context with fluorescence microscopy. Specific labeling via bio-orthogonal tetrazine chemistry combines minimal label size rapid kinetics. At same time, fluorogenic tetrazine–dye conjugates exhibit efficient quenching dyes prior to target binding. However, live-cell compatible long-wavelength strong fluorogenicity have been difficult realize. Here, we report close proximity distance between and fluorophore....
We introduce a family of bright, rhodamine-based calcium indicators with tuneable affinities and colors. The can be specifically localized to different cellular compartments are compatible both fluorescence bioluminescence readouts through conjugation HaloTag fusion proteins. Importantly, their increase in upon localization enables no-wash live-cell imaging, which greatly facilitates use biological assays. Applications as fluorescent rat hippocampal neurons include the detection single...
Abstract Oligoarenes are regarded as subunits of π‐extended carbon nanoforms, such graphene and nanotubes, with exceptional technological importance. Fused arenes can thus provide fundamental insight into the nature electronic properties fused polyaromatic rings pave way for design extended graphene‐like materials. However, large often show low stability. Herein we report straightforward preparation linearly diphosphahexaarenes containing two six‐membered phosphorus heterocycles. They highly...
Abstract Oligoarenes are regarded as subunits of π‐extended carbon nanoforms, such graphene and nanotubes, with exceptional technological importance. Fused arenes can thus provide fundamental insight into the nature electronic properties fused polyaromatic rings pave way for design extended graphene‐like materials. However, large often show low stability. Herein we report straightforward preparation linearly diphosphahexaarenes containing two six‐membered phosphorus heterocycles. They highly...
Abstract Small-molecule fluorophores enable the observation of biomolecules in their native context with fluorescence microscopy. Specific labelling via bioorthogonal tetrazine chemistry confers minimal label size and rapid kinetics. At same time, fluorogenic tetrazine-dye conjugates exhibit efficient quenching dyes prior to target binding. However, live-cell compatible long-wavelength strong fluorogenicity have been difficult realize. Here, we report close proximity distance between...
Abstract We introduce a family of bright, rhodamine-based calcium indicators with tuneable affinities and colors. The can be specifically localized to different cellular compartments are compatible both fluorescence bioluminescence readouts through conjugation HaloTag fusion proteins. Importantly, their increase in upon localization enables no-wash live-cell imaging, which greatly facilitates use biological assays. Applications as fluorescent rat hippocampal neurons include the detection...
Despite recent advances in reinforcement learning (RL), its application safety critical domains like autonomous vehicles is still challenging. Although punishing RL agents for risky situations can help to learn safe policies, it may also lead highly conservative behavior. In this paper, we propose a distributional framework order adaptive policies that tune their level of conservativity at run-time based on the desired comfort and utility. Using proactive verification approach, proposed...