A5073324843- Dialysis and Renal Disease Management
- Poisoning and overdose treatments
- Reconstructive Surgery and Microvascular Techniques
- Renal function and acid-base balance
- Acute Kidney Injury Research
- RNA Interference and Gene Delivery
- Body Contouring and Surgery
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Vitamin C and Antioxidants Research
- vaccines and immunoinformatics approaches
- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Metabolism and Genetic Disorders
- Reconstructive Facial Surgery Techniques
- Facial Rejuvenation and Surgery Techniques
- Breast Implant and Reconstruction
- Surgical Sutures and Adhesives
- Ocular Disorders and Treatments
- Prenatal Screening and Diagnostics
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
University of Campania "Luigi Vanvitelli"
2022-2025
University of Rome Tor Vergata
1988-2001
Confederazione Nazionale dell'Artigianato e Della Piccola e Media Impresa
2001
Istituto di Sessuologia Clinica
1996
Istituto di Tipizzazione Tissutale e Problemi della Dialisi
1988-1992
The present review focuses on synthetic peptide-based vaccine strategies in the context of anticancer intervention, paying attention to critical aspects such as peptide epitope selection, adjuvant integration, and nuanced classification cancer vaccines. Within this discussion, we delve into diverse array vaccines, each derived from tumor-associated antigens (TAAs), including melanoma antigen recognized by T cells 1 (Melan-A or MART-1), mucin (MUC1), human epidermal growth factor receptor 2...
The integration of low-frequency ultrasound with Solid-Phase Peptide Synthesis (SPPS) was explored to establish a Sustainable Ultrasound-assisted (SUS-SPPS) method. This innovative approach significantly reduces solvent consumption, washing steps, time, and reagent usage compared conventional manual SPPS protocols. SUS-SPPS method exploits at every stage synthesis work-up, reducing the process just two steps. first step sequentially combines Fmoc-amino acid coupling, capping unreacted amino...
Vaccinology has revolutionized modern medicine, delivering groundbreaking solutions to prevent and control infectious diseases while pioneering innovative strategies tackle non-infectious challenges, including cancer. Traditional vaccines faced inherent limitations, driving...
Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of PNA synthesis (US-PNAS). When compared with standard protocols, application so-obtained US-PNAS approach succeeded improving crude product purities isolated yields different PNA, including small or medium-sized (5-mer 9-mer), complex purine-rich sequences (like a 5-mer Guanine homoligomer...
Reconstructing large defects of the columella and upper lip is an interesting challenge in facial reconstruction due to high visibility this aesthetic subunit difficulties posed by unique characteristics skin these areas, which differs from that surrounding regions. Among various techniques proposed, use local flaps remains most commonly used effective method type reconstruction. A 47-year-old man good clinical condition presented with a nodular lesion on lip. The was excised (revealing it...
We described previously that in the erythrocytes and mononuclear blood cells from uremic patients on chronic hemodialysis, membrane concentrations of malonyldialdehyde (MDA), resulting peroxidation polyunsaturated fatty acids (PUFA) itself increased, vitamin E (VIT E), major antioxidizing agent, were lower. In present study we analysed whether similar oxidative damage is seen serum hemodialysis acid pattern affected. No evidence was found during MDA VIT remaining constant before after...
Continuous Renal Replacement Therapy (CRRT) indication is still discussed. We report our experience on 98 patients affected with Multiple Organ System Failure (MOSF) and renal failure (acute or chronic) requiring dialysis timely treated by CRRT. Mortality after 5 days of ICU permanence was 60.2%; the remaining 39 were discharged within 21 received CRRT treatment for 6.36 +/- 5.59 days. APACHE II score not able to predict outcome suffering from acute (ARF). On contrary, Systemic Inflammatory...
Synthetic nucleic acid interactors represent an exciting research field due to their biotechnological and potential therapeutic applications. The translation of these molecules into drugs is a long difficult process that justifies the continuous new chemotypes endowed with favorable binding, pharmacokinetic pharmacodynamic properties. In this scenario, we describe synthesis two sets homo-thymine nucleopeptides, in which nucleobases are inserted peptide structure, investigate role...
Summary: The traumatic pathology of the lower limb represents a very complex branch medicine, which, despite wide presence guidelines, aimed at regulating various therapeutic procedures, and is still greatly influenced by random variables multiple responses to treatments. In this report, we present our experience with borderline case, where timing trauma patient’s characteristics made it difficult use most recommended procedures in management.
There are various models for practicing microsurgical anastomoses, from synthetic to ex vivo and in biological ones. In this study, we present the domestic turkey (
The present study describes a small library of peptides derived from potent and selective CXCR4 antagonist (3), wherein the native disulfide bond is replaced using side-chain to tail macrolactamization technique vary ring size amino acid composition. were preliminary assessed for their ability interfere with interaction between receptor anti-CXCR4 PE-conjugated antibody clone 12G5. Two promising candidates (13 17) identified further evaluated in 125I-CXCL12 competition binding assay,...
BackgroundAbdominoplasty is a common surgical procedure where excess abdominal skin and fat reduced to improve body contouring. Fibrin sealant has been proposed reduce post-surgical bleeding exudation. In this study we evaluated if there was significant statistical difference between the use or not of fibrin glue in abdominoplasty surgery reducing exudation by amount drain output.Material methodsA retrospective chart review on 68 post-bariatric patients (fifty-eight females, ten males)...
Recently, we have demonstrated that hemodialysis (HD) patients higher serum and lower erythrocyte concentrations of vitamin E than controls. It is known transfer from to mostly due high-density lipoproteins (HDL). For a better definition the pattern distribution in HD patients, dosed amount bound HDL fraction. In 8 healthy controls, determined concentration HDL-bound E. The latest was obtained on an ultracentrifuged fractions been found contain larger amounts previously described confirmed...
To determine whether pregnancy has an adverse influence on survival or graft function, a retrospective study was conducted. A total of 321 renal transplant(rTx) patients were followed day hospital basis Tor Vergata University Rome between January 1981 and April 1996. Out 90 female subjects, 74 childbearing age (less than 45 years) underwent the study. Six women had 7 pregnancies which resulted in 5 live births two first trimester abortions. In one case occurred at 4 months after rTx:...