A5084057400- Bacillus and Francisella bacterial research
- Bacteriophages and microbial interactions
- Poxvirus research and outbreaks
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Inactivation Methods
- Bacterial Genetics and Biotechnology
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
University College of Medical Sciences
2023
Guru Teg Bahadur Hospital
2023
Defence Research and Development Establishment
2016-2020
Background: Anthrax, a disease of bioterrorism and public health importance is caused by the Gram positive, spore-forming bacterium, Bacillus anthracis. Anthrax toxin, tripartite toxin composed protective antigen (PA), lethal factor (LF) or edema (EF). PA major protein which facilitates entry component either factor. Recombinant has been suitable target for anthrax vaccine worldwide. However, instead full PA, its domains are reported to provide protection. LF also contributes...
Category A classified Bacillus anthracis is highly fatal pathogen that causes anthrax and creates challenges for global security public health. In this study, development of a safe ideal next-generation subunit vaccine has been evaluated in mouse model.Protective antigen (PA) BA3338, surface layer homology (SLH) domain possessing protein were cloned, expressed heterologous system purified by IMAC. Recombinant PA BA3338 with alum administered alone or combination. The humoral cell-mediated...
Background: over the past decade, dependency on colistin as a last resort antibiotic has driven global emergence of resistance among many bacterial species. This study comparatively evaluated Minimum Inhibitory Concentration (MIC) by various phenotypic methods, including reference method Broth Microdilution (BMD), other approved methods Colistin Disk Elution (CBDE), and Agar Test (CAT) widely available Epsilometer (E-test) Multidrug Resistant (MDR) Gram-negative bacteria. Methods: ninety...
Background: Anthrax, caused by Bacillus anthracis is known to occur globally since antiquity. In human, the disease manifests itself in one of three forms: cutaneous, gastrointestinal or pulmonary depending upon route spore entry. Cutaneous anthrax a public health importance also country like India. Therefore, there need develop an improved, simple, sensitive, specific, user-friendly, field usable, cost-effective and universal detection method for serodiagnosis human animals. Methods &...