A5103525835- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Urologic and reproductive health conditions
- Vascular Malformations and Hemangiomas
- PI3K/AKT/mTOR signaling in cancer
- Aortic Thrombus and Embolism
- Chemical Reactions and Isotopes
- Sarcoma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- RNA regulation and disease
- Adenosine and Purinergic Signaling
- Science, Research, and Medicine
- Surgical site infection prevention
- Genetic factors in colorectal cancer
- Orthopedic Infections and Treatments
- Autophagy in Disease and Therapy
Sungkyunkwan University
2024
Effective intracellular delivery of therapeutic proteins can potentially treat a wide array diseases. However, efficient functional across the cell membrane remains challenging. Exosomes are nanosized vesicles naturally secreted by various types cells and may serve as promising nanocarriers for biomolecules. Here, we engineered exosomes equipped with photoinducible cargo protein release system, termed mMaple3-mediated loading into from exosome (MAPLEX), in which be loaded fusing them...
Abstract The application of extracellular vesicles (EVs) as vehicles for anti‐Parkinson's agents represents a significant advance, yet their clinical translation is hampered by challenges in efficient brain delivery and complex blood‐brain barrier (BBB) targeting strategies. In this study, we engineered dopamine onto the surface adipose‐derived stem cell EVs (Dopa‐EVs) utilizing facile, two‐step cross‐linking approach. This engineering enhanced neuronal uptake primary neurons neuroblastoma...
Ras is a small GTP binding protein. Specific point mutations can lead to constant activation of molecule. Over expression mutated molecule induced morphological transformation NIH3T3 cells in culture and these transformed had the ability induce tumors nude mice. The play significant role tumor formation development. critical signaling human cancer proved by fact that it one most highly genes cancer, with approximately 90% incidence activating mutation pancreatic 50% colon 30% many other types.