M.K. White

ORCID: 0009-0004-5301-8711
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About
Contact & Profiles
Research Areas
  • Nuclear and radioactivity studies
  • Graphite, nuclear technology, radiation studies
  • Risk and Safety Analysis
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • Immunotherapy and Immune Responses
  • Building Energy and Comfort Optimization
  • Nuclear reactor physics and engineering
  • Erosion and Abrasive Machining
  • High-Temperature Coating Behaviors
  • Metallurgical Processes and Thermodynamics
  • Risk Perception and Management
  • Recycling and Waste Management Techniques
  • Metal and Thin Film Mechanics
  • Wind and Air Flow Studies
  • Nuclear Materials and Properties
  • Advanced Sensor Technologies Research
  • Cancer Immunotherapy and Biomarkers
  • Aerosol Filtration and Electrostatic Precipitation
  • Infection Control and Ventilation
  • Electrokinetic Soil Remediation Techniques
  • Heat Transfer and Optimization
  • Gynecological conditions and treatments
  • Electric Vehicles and Infrastructure
  • Facilities and Workplace Management

AbbVie (United States)
2023

Building Research Establishment
1992-1999

United States Department of Commerce
1999

Office of Environmental Management
1999

Pacific Northwest National Laboratory
1978-1999

Office of Scientific and Technical Information
1999

Westinghouse Electric (United States)
1988

Centers for Disease Control and Prevention
1977

As part of public health preparedness for infectious disease threats, CDC collaborates with other U.S. officials to ensure that the Laboratory Response Network (LRN) has diagnostic tools detect Orthopoxviruses, genus includes Variola virus, causative agent smallpox. LRN is a network state and local health, federal, Department Defense (DOD), veterinary, food, environmental testing laboratories. developed, Food Drug Administration (FDA) granted 510(k) clearance* Non-variola Orthopoxvirus...

10.15585/mmwr.mm7128e1 article EN MMWR Morbidity and Mortality Weekly Report 2022-07-08

10.1016/0002-9378(77)90642-1 article EN American Journal of Obstetrics and Gynecology 1977-11-01

Renewed interest is being shown in designing for natural ventilation, as a means of avoiding the need air conditioning. This has come about result concern local and global environmental issues related to conditioned buildings. On level there is, example, risk health-related problems such 'sick building syndrome'. Global depletion ozone layer atmospheric greenhouse effect. It generally acknowledged that, operation, depleting gases are released from refrigeration plant most buildings; they...

10.1177/014362449201300407 article EN Building Services Engineering Research and Technology 1992-11-01

CD3 bispecific T-cell engagers (TCE), comprised of a tumor-targeting domain linked to binding domain, function by bridging target-positive tumors and CD3-expressing effector T cells enabling redirected cell-mediated killing tumor cells. Although the majority molecules in clinical development incorporate antibody-based domains, many tumor-associated antigens derive from intracellular proteins are not accessible targeting via antibody. Intracellular processed into short peptide fragments...

10.1158/1535-7163.mct-22-0770 article EN Molecular Cancer Therapeutics 2023-06-09

This paper is based on measured environmental condi tions and ventilation rates during a summer period in the occupied naturally ventilated passively cooled Envi ronmental Building at Research Establish ment, Garston, UK. Initially, comfort air quality conditions first (typical) floor of building are discussed. These found to be satisfacto ry. The then goes investigate cooling effectiveness various flowpaths associated thermal mass. In particular, focuses south façade passive stacks their...

10.1177/1420326x9900800506 article EN Indoor and Built Environment 1999-09-01

<div>Abstract<p>CD3 bispecific T cell engagers (TCE), comprised of a tumor targeting domain linked to CD3 binding domain, function by bridging target-positive tumors and CD3-expressing effector cells enabling redirected cell-mediated killing cells. Although the majority molecules in clinical development incorporate tumor-targeting antibody-based domains, many tumor-associated antigens derive from intracellular proteins are not accessible via antibody. Intracellular processed into...

10.1158/1535-7163.c.6769262.v2 preprint EN 2024-09-16

<p>A prostate tumor cell line (PC3M-A2/beta 2M) was inoculated subcutaneously in the right flank of CD34-humanized NSG mice. Mice were treated intravenously at indicated time points with either vehicle or an ABBV-184 precursor molecule, and size monitored. Tumors experienced transient regression growth inhibition prior to harvest for analysis tumor-infiltrating immune cells.</p>

10.1158/1535-7163.27036151 preprint EN 2024-09-16

<p>A prostate tumor cell line (PC3M-A2/beta 2M) was inoculated subcutaneously in the right flank of CD34-humanized NSG mice. Mice were treated intravenously at indicated time points with either vehicle or an ABBV-184 precursor molecule, and size monitored. Tumors experienced transient regression growth inhibition prior to harvest for analysis tumor-infiltrating immune cells.</p>

10.1158/1535-7163.27036151.v1 preprint EN 2024-09-16

This paper is based on measured environmental conditions and ventilation rates during a summer period in the occupied naturally ventilated passively cooled Environmental Building at Research Establishment, Garston, UK. Initially, comfort air quality first (typical) floor of building are discussed. These found to be satisfactory. The then goes investigate cooling effectiveness various flowpaths associated thermal mass. In particular, focuses south façade passive stacks their relative...

10.1159/000024659 article EN Indoor and Built Environment 1999-01-01

<div>Abstract<p>CD3 bispecific T cell engagers (TCE), comprised of a tumor targeting domain linked to CD3 binding domain, function by bridging target-positive tumors and CD3-expressing effector cells enabling redirected cell-mediated killing cells. Although the majority molecules in clinical development incorporate tumor-targeting antibody-based domains, many tumor-associated antigens derive from intracellular proteins are not accessible via antibody. Intracellular processed into...

10.1158/1535-7163.c.6769262 preprint EN 2023-08-01

<p>A prostate tumor cell line (PC3M-A2/beta 2M) was inoculated subcutaneously in the right flank of CD34-humanized NSG mice. Mice were treated intravenously at indicated time points with either vehicle or an ABBV-184 precursor molecule, and size monitored. Tumors experienced transient regression growth inhibition prior to harvest for analysis tumor-infiltrating immune cells.</p>

10.1158/1535-7163.23814242 preprint EN cc-by 2023-08-01

<p>A prostate tumor cell line (PC3M-A2/beta 2M) was inoculated subcutaneously in the right flank of CD34-humanized NSG mice. Mice were treated intravenously at indicated time points with either vehicle or an ABBV-184 precursor molecule, and size monitored. Tumors experienced transient regression growth inhibition prior to harvest for analysis tumor-infiltrating immune cells.</p>

10.1158/1535-7163.23814242.v1 preprint EN cc-by 2023-08-01

<div>Abstract<p>CD3 bispecific T-cell engagers (TCE), comprised of a tumor-targeting domain linked to CD3 binding domain, function by bridging target-positive tumors and CD3-expressing effector T cells enabling redirected cell–mediated killing tumor cells. Although the majority molecules in clinical development incorporate antibody-based domains, many tumor-associated antigens derive from intracellular proteins are not accessible targeting via antibody. Intracellular processed...

10.1158/1535-7163.c.6769262.v1 preprint EN 2023-08-01

The storage, environmental testing, culture and sterilisation of samples in industry requires the use temperature controlled enclosures, such as freezers, fridges, incubators, sterilisers chambers. In order to determine effectiveness these mapping test volume is carried out identify thermal variations with respect chamber duration. This a regulatory requirement some industries. Currently there are variety methods employed perform mapping, which can lead inconsistencies give calibration...

10.1063/1.4819656 article EN AIP conference proceedings 2013-01-01
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