A5100650044- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Muscle Physiology and Disorders
- Dermatological and COVID-19 studies
- Congenital Anomalies and Fetal Surgery
- Cellular Mechanics and Interactions
- Tumors and Oncological Cases
- Chronic Lymphocytic Leukemia Research
- biodegradable polymer synthesis and properties
- RNA Research and Splicing
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
Fondazione IRCCS Istituto Neurologico Carlo Besta
2022-2024
University of Milan
2024
Background and objectives Multisystem involvement in spinal muscular atrophy (SMA) is gaining prominence since different therapeutic options are emerging, making the way for new SMA phenotypes consequent challenges clinical care. Defective immune organs have been found preclinical models of SMA, suggesting an system disease. However, state patients has not investigated so far. Here, we aimed to evaluate innate adaptive immunity pattern type 1 3 patients, before after nusinersen treatment....
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. Considerable evidence indicates that early skeletal muscle atrophy plays crucial role in the pathogenesis, leading to an altered muscle-motor neuron crosstalk that, turn, may contribute degeneration. Currently, there no effective treatment for ALS, highlighting need dig deeper into pathological mechanisms developing innovative therapeutic strategies. FM19G11 novel drug able modulate global...
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive, irreversible loss of upper and lower motor neurons (UMNs, LMNs). MN axonal dysfunctions are emerging as relevant pathogenic events since early ALS stages. However, exact molecular mechanisms leading to axon degeneration in still need be clarified. MicroRNA (miRNA) dysregulation plays a critical role pathogenesis neuromuscular diseases. These molecules represent promising biomarkers for these conditions their expression...
Efficient intracellular delivery of exogenous (nano)materials is critical for both research and therapeutic applications. The physicochemical properties the cargo play a crucial role in determining internalization efficacy. Consequently, significant efforts are focused on developing innovative effective methodologies to optimize (nano)material delivery. In this study, we utilized osmotic shock enhance (nano)cargos internalization. We examined effects hypotonic/hypertonic primary cell lines,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)