A5000950592- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Pluripotent Stem Cells Research
- Air Quality and Health Impacts
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Adrenal and Paraganglionic Tumors
- Body Contouring and Surgery
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Tuberculosis Research and Epidemiology
- Dietary Effects on Health
- Obesity and Health Practices
- Hormonal Regulation and Hypertension
- Diagnosis and treatment of tuberculosis
- Galectins and Cancer Biology
- Biomarkers in Disease Mechanisms
- Chronic Lymphocytic Leukemia Research
University of Zurich
2009-2025
University Hospital of Zurich
2012-2025
University Hospital of Basel
2013-2024
Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus
2024
University of Basel
2017-2023
Spital Limmattal
2023
Joslin Diabetes Center
2014-2017
Harvard University
2011-2015
OBJECTIVE Metabolic activation of the innate immune system governed by interleukin (IL)-1β contributes to β-cell failure in type 2 diabetes. Gevokizumab is a novel, human-engineered monoclonal anti–IL-1β antibody. We evaluated safety and biological activity gevokizumab patients with RESEARCH DESIGN AND METHODS In placebo-controlled, dose-escalation study, total 98 were randomly assigned placebo (17 subjects) or (81 at increasing doses dosing schedules. The primary objective study was...
Interleukin-1β (IL-1β) is a key cytokine involved in inflammatory illnesses including rare hereditary diseases and common chronic conditions as gout, rheumatoid arthritis, type 2 diabetes mellitus, suggesting reduction of IL-1β activity new treatment strategy. The objective our study was to assess safety, antibody response, preliminary efficacy novel vaccine against IL-1β. hIL1bQb consisting full-length, recombinant coupled virus-like particles tested preclinical clinical, randomized,...
Chronic low-grade inflammation is a hallmark of obesity and associated with cardiovascular complications. However, it remains unclear where this starts. As the gut constantly exposed to food, microbiota, metabolites, we hypothesized that mucosal immunity triggers an innate inflammatory response in obesity. We characterized five distinct macrophage subpopulations (P1-P5) along gastrointestinal tract blood monocyte (classical, non-classical, intermediate), which replenish intestinal...
Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining intestinal health. However, the molecular pathways that regulate goblet cell function remain largely unknown. Although GPR35 is highly expressed in colonic epithelial cells, its importance promoting barrier unclear. In this study, we show Gpr35 plays critical role function. mice, cell-type-specific deletion of but not macrophages results depletion...
Stem cells hold great promise for pancreatic beta cell replacement therapy diabetes. In type 1 diabetes, are mostly destroyed, and in 2 diabetes numbers reduced by 40% to 60%. The proof-of-principle that cellular transplants of islets, which contain insulin-secreting cells, can reverse the hyperglycemia has been established, there is now a need find an adequate source islet cells. Human embryonic stem be directed become fully developed expectation induced pluripotent (iPS) similarly...
Abstract Aims/hypothesis Colony stimulating factor 1 (CSF1) promotes the proliferation, differentiation and survival of macrophages, which have been implicated in both beneficial detrimental effects on glucose metabolism. However, physiological role CSF1 signalling homeostasis potential therapeutic implications modulating this pathway are not known. We aimed to study composition tissue macrophages (and other immune cells) following receptor (CSF1R) inhibition elucidate metabolic consequences...
Abstract Background Air pollution has emerged as an unexpected risk factor for diabetes. However, the mechanism behind remains ill-defined. So far, lung been considered main target organ of air pollution. In contrast, gut received little scientific attention. Since particles can reach after mucociliary clearance from lungs and through contaminated food, our aim was to assess whether exposure deposition in or drive metabolic dysfunction mice. Methods To study effects versus exposure, we...
There has been great interest in the extent of β-cell regeneration after pancreatic duct ligation (PDL) and whether α- to conversion might account for near-complete loss. To assess these questions, we established a PDL-model adult male rats almost complete beta-cell depletion achieved by giving single high dose streptozocin (STZ) fasted state. Because resultant severe diabetes, were given islet cell transplants allow long-term follow-up. Although animals followed up 10 months, there was no...
Abstract The obesity epidemic continues to worsen worldwide. However, the mechanisms initiating glucose dysregulation in remain poorly understood. We assessed role that colonic macrophage subpopulations play homeostasis mice fed a high-fat diet (HFD). Concurrent with intolerance, pro-inflammatory/monocyte-derived macrophages increased HFD. A link between numbers and glycemia was established by pharmacological dose-dependent ablation of macrophages. In particular, colon-specific depletion...
Abstract Aims Effective diabetes management requires adherence to medication regimens and nutritional guidelines, underscoring the importance of health literacy. Our study aimed develop validate nutrition knowledge questionnaires correlate diabetes‐specific literacy with glucose metrics in people type 1 2 diabetes. Methods In a cross‐sectional at Swiss tertiary centre, were developed assess 289 participants on insulin pumps or basal‐bolus 222 without insulin. Questionnaire validation...
Abstract Reprogramming technology has opened the possibility of converting one cell type into another by forced expression transgenes. Transduction adenoviral vectors encoding 3 pancreatic transcription factors, Pdx1, Ngn3, and MafA, mouse pancreas results in direct reprogramming exocrine cells to insulin-producing β-like cells. We hypothesized that cultured adult duct could be reprogrammed become β-cells adenoviral-mediated this same combination factors. Exocrine were isolated from insulin...
Inflammatory bowel disease (IBD) occurring following allogeneic stem cell transplantation (aSCT) is a very rare condition. The underlying pathogenesis needs to be better defined. There currently no systematic effort exclude loss- or gain-of-function mutations in immune-related genes donors. This despite the fact that more than 100 inborn errors of immunity may cause contribute IBD. We have molecularly characterized patient who developed fulminant inflammatory aSCT with stable 100%...
Weight loss following OAGB surgery in obese mice was not influenced by BPL length, but a longer associated with improved metabolic outcomes, including glucose and lipid homeostasis. These changes could be mediated bile acids upon altered gut microbiota. Further validation of these findings is required through randomized human study.
The overall aim of this study was to evaluate the implementation sodium-glucose cotransporter 2 inhibitors (SGLT2i) among patients in tertiary care with type diabetes mellitus (T2DM) and chronic kidney disease (CKD). cross-sectional analysis based on outpatients enrolled Swiss Diabetes Registry T2DM a visit January 1, 2020-March 31, 2021. Prevalence CKD ascertained as an estimated glomerular filtration rate <60 mL/min/1.73 m2 and/or persistent albuminuria defined by Kidney Disease Improving...
Macrophages have been recognized as key players in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether pharmacological attenuation of macrophages can be achieved by imatinib, an anti-leukemia drug with known anti-inflammatory and anti-diabetic properties, how this impacts on NAFLD. We analyzed the pro- gene expression murine human monocytes vitro presence or absence imatinib. In a time-resolved study, we characterized metabolic manifestations such hepatic steatosis,...
Abstract Background We previously found that air pollution particles reaching the gastrointestinal tract elicit gut inflammation as shown by up-regulated gene expression of pro-inflammatory cytokines and monocyte/macrophage markers. This inflammatory response was associated with beta-cell dysfunction glucose intolerance. So far, it remains unclear whether changes upon oral exposure are causally linked to development diabetes. Hence, our aim assess role immune cells in mediating intolerance...