A5103441499- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Lymphoma Diagnosis and Treatment
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Cutaneous Melanoma Detection and Management
- Urticaria and Related Conditions
- Oral Health Pathology and Treatment
- Vascular Tumors and Angiosarcomas
- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders
- Genital Health and Disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Psoriasis: Treatment and Pathogenesis
- Lymphatic System and Diseases
- Skin Diseases and Diabetes
- Vascular Malformations and Hemangiomas
- Healthcare Policy and Management
- Immune Cell Function and Interaction
- Skin and Cellular Biology Research
- Potassium and Related Disorders
- Advanced Biosensing Techniques and Applications
University of Missouri–Kansas City
2025
Princess of Wales Hospital
2005-2007
St Thomas' Hospital
1999-2005
St. John's University
2001-2003
Ealing Hospital
2001-2003
Lambeth Hospital
2002
St. Thomas Hospital
2001
King's College London
2001
Ealing Hospital NHS Trust
2001
Guy's Hospital
2001
Abstract In a significant proportion of melanoma patients, CTL specific for the melan-A26/7–35 epitope can be detected in peripheral blood using HLA-A2/peptide tetramers. However, functional capacity these has been controversial, since although they prove to effective killers after vitro expansion, some patients have blunted activation responses ex vivo. We used phenotypic markers characterize melan-A tetramer+ cells both normal individuals and correlated with vivo assays function. Melanoma...
Summary We report an open single-centre trial to assess the efficacy of topical pseudocatalase mousse applied twice daily hands and face vitiligo patients, in combination with twice-weekly suberythemogenic narrowband UVB phototherapy. The regime was generally safe well tolerated, although several patients experienced mild transient skin rashes association application one patient suffered severe pruritus. primary variable percentage change area affected by as assessed digital interpretation...
ABSTRACT Angiotensin-converting enzyme inhibitors are a common cause of drug-induced angioedema, which rarely affects the gut. We present 32-year-old White woman with Crohn's disease on lisinopril experiencing 1 year episodic abdominal pain, nausea, and vomiting, prompting multiple steroid tapers switch in biologic therapy. She was hospitalized profoundly hypotensive arrival. Initial imaging showed marked small bowel wall thickening free fluid abdomen. had rapid symptomatic radiographic...
Reduced bone mineral density (BMD), the major risk factor for osteoporotic fracture, has been linked to palmoplantar pustular psoriasis, but no significant studies have examined BMD in chronic plaque psoriasis (CPP). In this study, in-patients with severe CPP had their measured at nondominant hip and lumbar spine using dual energy X-ray absorbtiometry. Ten male 10 female Caucasian patients were recruited, a mean age of 47 years (range 20--71 years). There differences between controls....
Lymphomatoid papulosis (LyP) is a chronic self-healing cutaneous eruption which clinically benign but histologically malignant. Lesions occur episodically over the trunk and limbs. We describe four patients with regional LyP. All were male, range in age at onset from 12 to 47 years. In all cases, lesions confined segmental unilateral area. Two had type A two B have long-term follow-up on one patient whose limited right buttock for more than 20 years before widespread developed. Another left...
Background and Objectives Laser-induced photo thermal damage has been combined with photodynamic therapy (PDT) using a systemic photosensitiser to treat vascular lesions. The efficacy of PDT 5-aminolaevulinic acid (5-ALA) as the pulsed dye laser (PDL) light source in port wine stains (PWS) is unknown. Study Designs/Materials Methods We conducted an internally controlled pilot study comparing PDL source, alone treatment PWS. Results PWS improved slightly all patients but no significant...
Sentinel node (SN) status is the most important prognostic indicator in patients with cutaneous melanoma without clinically evident metastatic spread, but procedure associated considerable morbidity. The LYVE-1 lymphatic marker offers possibility of studying lymphangiogenesis and tumour metastasis within primary excision.To establish whether vessel numbers/distribution correlated SN status. To assess cells were easily demonstrable lymphatics could be used as a surrogate for status.Double...
Livedoid vasculitis is a chronic condition characterized by recurrent painful ulceration of the lower limbs, which heals to leave atrophie blanche surrounded hyperpigmentation and telangiectasia. We report two patients with livedoid who, after failure conventional therapies, responded intravenous immunoglobulin (IVIg). There was healing areas active improvement erythema, swelling pain. IVIg has been used successfully treat variety vasculitic disorders appears be well tolerated. suggest that...
Sézary syndrome (SS) is characterized by a malignant proliferation of CD4+ve T cells, which may result in degree immunoparesis. Immunosuppression associated with an increased incidence internal neoplasms and high rate nonmelanoma skin cancer, particularly squamous cell carcinoma. Therefore, we reviewed the secondary patients SS.Of 71 SS, 16 (23%) developed 19 tertiary neoplasms. These included 8 cutaneous carcinomas, 2 carcinomas oral mucosa, 9 other The was twice that reported similar age...
S100 protein is an acidic calcium binding that expressed by melanoma cells. Elevated serum values of have been described in metastatic disease and it has suggested may be used as adjunct to staging monitoring treatment. Micrometastatic the sentinel lymph node can demonstrated biopsy (SNB) status known most important predictor relapse.To determine whether concentrations could predict presence micrometastatic disease.Thirty-one patients with primary cutaneous > 1 mm were recruited from...
Chronic actinic dermatitis (CAD) is a disorder characterized by an often severe persistent eczematous eruption induced exposure to ultraviolet radiation. Treatment involves photoprotective measures and topical corticosteroid therapy in more cases, systemic immunosuppression. Occasionally, however, the condition can prove very resistant all be severely disabling. We report patient with CAD who resisted standard treatments, but responded tacrolimus ointment 0.1% (Protopic).
Lymphomatoid contact dermatitis refers to the relatively little known phenomenon of allergic producing histological features suggestive cutaneous T-cell lymphoma. We report first case lymphomatoid in response para-tertyl-butyl phenol resin.
Journal Article Lymphocytic infiltrates as a presenting feature of Sweet's syndrome with myelodysplasia and response to cyclophosphamide Get access A.V. Evans, Evans St John's Institute Dermatology, Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K Alun V.Evans. E‐mail: alun@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar R.A. Sabroe, Sabroe Greenwich District SE10 9HE, K. Liddell, Liddell Eastbourne General BN21 2UD, R. Russell‐Jones British...
Journal Article Tea tree oil dermatitis associated with linear IgA disease Get access C. M. Perrett, Perrett Department of Dermatology, Ealing Hospital, Middlesex, UK Uxbridge Road, Middlesex UB1 3HW, UK. Tel.: 020 89675435. Fax: 89675612. E‐mail: conalperrett@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar A. V. Evans, Evans R. Russell‐Jones Clinical and Experimental Volume 28, Issue 2, 1 March 2003, Pages 167–170,...
Journal Article Giant condyloma of Buschke–Loewenstein in association with erythroderma Get access F. C. Antony, Antony Department Dermatology and Flat 4, 36 Lingfield Road, Wimbledon, London SW19 4PZ, UK. Tel.: +44 208 946 5884. Fax: 7253297. E‐mail: fiantony@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar M. Ardern‐Jones, Ardern‐Jones A. V. Evans, Evans T. Rosenbaum, Rosenbaum *Urology, Ealing Hospital, Uxbridge Southall, Middlesex, UK R. Russell‐Jones...
We report a case of lichen planus affecting the toe nails without involvement skin or finger nails. To our knowledge this is first time has been reported. also discuss clinical features, histology and treatment nail planus.
Approximately 10% of metastases from all primary neoplasms involve the skin, but for malignant melanoma figure is 44%.1 In some cases this presenting feature, either because lesion has regressed completely or it been unnoticed ignored by patient. Occasionally originated at an extracutaneous site such as retina anal canal. Metastases cutaneous normally present flesh coloured papules nodules in skin. Only about a third are pigmented ulcerated. We report case which imitated herpes zoster. This...