A5088645382- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Prostate Cancer Treatment and Research
- Myasthenia Gravis and Thymoma
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Peripheral Neuropathies and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Diabetes and associated disorders
- Antifungal resistance and susceptibility
- CAR-T cell therapy research
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- RNA regulation and disease
- Cancer-related Molecular Pathways
- Advanced battery technologies research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Hereditary Neurological Disorders
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
Northwestern University
2023-2025
Chengdu University of Traditional Chinese Medicine
2024
University of Illinois Chicago
2019
University of Chicago
2013-2015
Seoul National University
2006-2009
Seoul National University Hospital
2005
Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation sirtuin 3. We generated an ACSS1-acetylation (Ac) mimic mouse, where lysine-635 was mutated glutamine (K635Q). Male Acss1 K635Q/K635Q mice were smaller with higher metabolic rate blood decreased liver/serum ATP lactate levels. After a 48-hour fast, presented hypothermia liver aberrations, including enlargement, discoloration, lipid droplet...
TP53 tumor suppressor is frequently altered in lethal, castration-resistant prostate cancer (CRPC). However, to date there are no effective treatments that specifically target alterations. Using transcriptomic and metabolomic analyses, we have shown here TP53-altered exhibits an increased dependency on asparagine (Asn) overexpresses Asn synthetase (ASNS), the enzyme catalyzing synthesis of Asn. Mechanistically, loss or mutation transcriptionally activated ASNS expression, directly via...
Summary The dietary supplement and prebiotic values of β ‐glucan‐rich products have been widely recognized approaches for modulating autoimmunity increasingly explored, we assess the impact oral administration high‐purity yeast ‐glucan ( YBG ) on gut immune function, microbiota type 1 diabetes (T1D) using mouse models. Oral this non‐digestible complex polysaccharide caused a dectin‐1‐dependent response involving increased expression interleukin‐10 IL ‐10), retinaldehyde dehydrogenase (Raldh)...
IL-10-competent subset within CD1d(hi)CD5(+) B cells, also known as B10 has been shown to regulate autoimmune diseases. Whether cells can prevent or suppress the development of experimental myasthenia gravis (EAMG) not studied. In this study, we investigated whether low-dose GM-CSF, which suppresses EAMG, expand in vivo, and adoptive transfer would EAMG. We found that treatment EAMG mice with GM-CSF increased proportion cells. vitro coculture studies revealed altered T cell cytokine profile...
Abstract central nervous system (CNS) inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging ISR protects remyelinating oligodendrocytes and promotes remyelination in presence inflammation. However, exact mechanisms through which this occurs remain unknown. Here, we investigated whether modulator Sephin1 combination with oligodendrocyte differentiation enhancing reagent bazedoxifene (BZA) is able to accelerate under inflammation,...
Although there have been many therapeutic options for allergic disease, the true allergen desensitization remains a challenging goal. The classic immunotherapy has limited efficacy, is inconvenient, and risk of anaphylaxis. Recent reports revealed that immunostimulatory DNA sequences (ISS-oligdeoxynucleotide [ODN], CpG motif) act as strong Th1 response-inducing adjuvants DNA-based vaccination might be an effective option. In this study, we investigate whether ISS-ODN/Dermatophagoides farinae...
Summary Spontaneous autoimmune polyneuropathy (SAP) in B7-2 knock-out non-obese diabetic (NOD) mice is mediated by myelin protein zero (P0)-reactive T helper type 1 (Th1) cells. In this study, we investigated the role of B cells SAP, focusing on CD19 as a potential therapeutic target. We found that P0-specific plasmablasts and were increased spleens SAP compared to wild-type NOD mice. Depletion with anti-CD19 monoclonal antibody (mAb) led attenuation disease severity when administered at 5...
<div>Abstract<p><i>TP53</i> tumor suppressor is frequently altered in lethal, castration-resistant prostate cancer (CRPC). However, to date there are no effective treatments that specifically target <i>TP53</i> alterations. Using transcriptomic and metabolomic analyses, we have shown here <i>TP53</i>-altered exhibits an increased dependency on asparagine (Asn) overexpresses Asn synthetase (ASNS), the enzyme catalyzing synthesis of Asn....
Abstract Spontaneous autoimmune polyneuropathy (SAP) in B7-2 knockout NOD mice mimics the progressive form of chronic inflammatory demyelinating polyradiculoneuropathy, and is mediated by myelin protein zero (P0)–reactive Th1 cells. In this study, we focused on effect deletion function dendritic cells (DCs) within context SAP. We found that development SAP was associated with a preponderance or increase CD11b+ DCs peripheral lymph nodes sciatic nerves. led to altered immunophenotypic...
Conclusion. We observed for the first time expression of Uteroglobin (UGB) in nasal mucosa mice. The results our study suggest that UGB may play an important role regulation inflammation allergic rhinitis (AR) as well lower airway inflammations. Objectives. is a protein secreted by epithelial lining organs communicating with external environment. Reports its immunomodulatory effects disease have been made, but true physiological still remains to be elucidated. In this we tried observe mice...
Power battery module under high-rate discharge conditions produces thermal aggregation phenomena. Generated heat during charging and discharging that distributes in inconsistently affects performance of so shortens its life. In this paper, a temperature equalization method is proposed with finite element analysis. The field different separators between cells simulated. Theoretical analysis result shows thin aluminum inside can effectively cool the improve uniformity, which enhance cycle life...
<div>Abstract<p><i>TP53</i> tumor suppressor is frequently altered in lethal, castration-resistant prostate cancer (CRPC). However, to date there are no effective treatments that specifically target <i>TP53</i> alterations. Using transcriptomic and metabolomic analyses, we have shown here <i>TP53</i>-altered exhibits an increased dependency on asparagine (Asn) overexpresses Asn synthetase (ASNS), the enzyme catalyzing synthesis of Asn....
<p>Supplementary Text and Figures</p>
<p>Supplementary Text and Figures</p>
ABSTRACT Since the dietary supplement and prebiotic value of β-glucan-rich products have been widely recognized approaches for modulating autoimmunity increasingly explored, we assessed impact oral administration high-pure yeast β-glucan (YBG) on gut immune function, microbiota type 1 diabetes (T1D) using mouse models. Oral this non-digestible complex polysaccharide caused a Dectin-1-dependent response involving increased expression IL10, retinaldehyde dehydrogenase (Raldh) pro-inflammatory...
Diseases of the Colon & Rectum: May 1968 - Volume 11 Issue 3 p 178-192 doi: 10.1007/BF02617293
Abstract IL-10-competent subset within CD1dhiCD5+ B cells, also known as B10 has been shown to regulate autoimmune diseases. Whether cells can prevent or suppress the development of experimental myasthenia gravis (EAMG) not studied. In this study, we investigated whether low dose granulocyte macrophage-colony stimulating factor (GM-CSF) expand in vivo, and adoptive transfer would EAMG. We found that treatment EAMG mice with low-dose GM-CSF increased proportion cells. vitro co-culture studies...
CNS inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging ISR protects remyelinating oligodendrocytes and promotes remyelination in presence (Chen et al., eLife , 2021). However, exact mechanisms through which this occurs remain unknown. Here, we investigated whether modulator Sephin1 combination with oligodendrocyte differentiation enhancing reagent bazedoxifene (BZA) is able to accelerate under inflammation, underlying mediating...