A5019121655- interferon and immune responses
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Advances in Oncology and Radiotherapy
- Mosquito-borne diseases and control
- NF-κB Signaling Pathways
Lanzhou Veterinary Research Institute
2023
Chinese Academy of Agricultural Sciences
2023
Lanzhou University
2023
Gansu Provincial Center for Disease Control and Prevention
2023
TLR/IL-1R signaling plays a critical role in sensing various harmful foreign pathogens and mounting efficient innate adaptive immune responses, it is tightly controlled by intracellular regulators at multiple levels. In particular, TOLLIP forms constitutive complex with IRAK1 sequesters the cytosol to maintain kinase an inactive conformation under unstimulated conditions. However, underlying mechanisms which dissociates from activate remain obscure. Herein, we show that BLK positively...