A5113243310- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
The University of Texas at Austin
2023-2025
Evidence from human self-report and rodent models indicate cocaine can induce a negative affective state marked by panic anxiety, which may reduce future use or promote co-use with opiates. Dynorphin-mediated signaling within the striatum is associated affect following withdrawal stress-induced seeking. Here, we used trace conditioning procedure to first establish optimum parameters capture this transient in wild type mice, then investigated striatal opioid peptides as substrate mediating...
Cocaine predictive cues and contexts exert powerful control over behaviour can incite cocaine seeking taking. This type of conditioned is encoded within striatal circuits, these circuits behaviours are, in part, regulated by opioid peptides receptors expressed medium spiny neurons. We previously showed that augmenting levels the peptide enkephalin striatum facilitates acquisition place preference (CPP), while receptor antagonists attenuate expression CPP. However, whether necessary for CPP...