A5074722814- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Work-Family Balance Challenges
- Anesthesia and Sedative Agents
- Thermal Regulation in Medicine
- Neuropeptides and Animal Physiology
- Employment and Welfare Studies
MSD (UK) Limited (United Kingdom)
2003-2004
Ninewells Hospital
2003
University of Dundee
2003
University College London
2000-2002
The specific mechanisms underlying general anesthesia are primarily unknown. intravenous anesthetic etomidate acts by potentiating GABA A receptors, with selectivity for β2 and β3 subunit-containing receptors determined a single asparagine residue. We generated genetically modified mouse containing an etomidate-insensitive subunit (β2 N265S) to determine the role of subunits in etomidate-induced anesthesia. Loss pedal withdrawal reflex burst suppression electroencephalogram were still...
Background The authors have previously described that the gamma-aminobutyric acid type A (GABAA) receptor beta 2N265S mutation results in a knock-in mouse with reduced sensitivity to etomidate. After recovery from etomidate anesthesia, these mice improved motor performance and less slow wave sleep. Because most clinically used anesthetics produce hypothermia, effect of this on core body temperature was investigated. Methods propofol were measured using radiotelemetry freely moving GABAA...
1 Neurones in the superior colliculus (SC) respond to novel sensory stimuli and response habituation is a key feature of this. It known that both ionotropic metabotropic glutamate (mGlu) receptors participate visual responses superficial SC neurones. A Group II III mGlu they may modulate specific neural pathways, possibly via presynaptic mechanisms. However, less about how this relate functions systems whole animals. We have therefore investigated whether these affect attributes SC. 2...
Group I metabotropic glutamate receptors (mGluRs) are expressed in cells the superficial layers of rat superior colliculus (SSC) and SSC afferents. The purpose this study was to investigate physiological effect mGluR activation on visual responses neurones using both vivo vitro techniques. In preparation, agonists antagonists were applied by iontophoresis single neurone activity recorded extracellularly anaesthetised rats. Application agonist ( S )‐3,5‐dihydroxyphenylglycine (DHPG) resulted...
Abstract There is evidence from immunohistochemical and in situ hybridization studies for the presence of Group I, II III metabotropic glutamate receptors (mGluRs) rat superficial superior colliculus (SSC). The purpose this study was to investigate if manipulation mGluRs affects visual responses SSC. Drugs were applied by iontophoresis single neuron activity recorded extracellularly. L‐AP4 (Group agonist) resulted a reduction most neurons, but also potentiation others. effect drug‐...