The effect of terahertz (THz) radiation on deep tissues human body has been considered negligible due to strong absorption by water molecules. However, we observed that the energy THz pulses transmits a millimeter thick in aqueous solution, possibly as shockwave, and demolishes actin filaments. Collapse filament induced irradiation was also living cells under an medium. We confirmed viability cell not affected exposure pulses. potential waves invasive method alter protein structure is demonstrated.

S-(+)-2-(4'-Isobutylphenyl)propionic acid [S-(+)-ibuprofen] was produced from racemic 2-(4'-isobutylphenyl)propionitrile (Ibu-CN) by an isolated bacterial strain, Acinetobacter sp. strain AK226. Ammonium acetate, acetonitrile, or n-butyronitrile as a carbon source in the culture medium effective for growth and induction of this activity. The optimum pH reaction around 8.0. S-(+)-Ibuprofen formed Ibu-CN resting cells present 95% enantiomeric excess. AK226 appeared to possess nitrilase because...

Biological phenomena induced by terahertz (THz) irradiation are described in recent reports, but underlying mechanisms, structural and dynamical change of specific molecules still unclear. In this paper, we performed time-lapse morphological analysis human cells found that THz halts cell division at cytokinesis. At the end cytokinesis, contractile ring, which consists filamentous actin (F-actin), needs to disappear; however, it remained for 1 hour under irradiation. Induction functional...

The crosstalk between actin and actin-related proteins (Arps), namely Arp2 Arp3, plays a central role in facilitating polymerization the cytoplasm also nucleus. Nuclear F-actin is required for transcriptional regulation, double-strand break repair, nuclear organization. formation of highly dynamic, suggesting involvement positive negative regulators polymerization. While assembly factors have been recently described, information about inhibitory still limited. protein Arp4 which...

The magnetic field surrounding an AC current-carrying wire is a promising source for energy harvesting. In this study, harvester developed based on the piezoelectric vibration harvester. A permanent magnet placed near vibrates by coupling with field. kinetic of can be converted effect. Theoretical analysis indicates that composed cantilever at free end should so and do not collide. Then, was fabricated using bimorph mechanical quality factor 66 generalized electromechanical (K2) 3.1%...

Abstract Biological phenomena induced by terahertz (THz) irradiation are described in recent reports, but underlying mechanisms, structural and dynamical change of specific molecules still unclear. In this paper, we performed time-lapse morphological analysis human cells found that THz halts cell division at cytokinesis. At the end cytokinesis, contractile ring, which consists filamentous actin (F-actin), needs to disappear; however, it remained for 1 hour under irradiation. Induction...

Abstract The effect of terahertz (THz) radiation on deep tissues human body has been considered negligible due to strong absorption by water molecules. However, we observed that the energy THz pulses transmits a millimeter thick in aqueous solution, possibly as shockwave, and demolishes actin filaments. Collapse filament induced irradiation was also living cells under an medium. We confirmed viability cell not affected exposure pulses. potential waves invasive method alter protein structure...

Abstract Actin exists in monomeric globular (G-) and polymerized filamentous (F-) forms the dynamics of its polymerization/depolymerization are tightly regulated both cytoplasm nucleus. Various essential functions nuclear actin have been identified including regulation gene expression involvement repair DNA double-strand breaks (DSB). Small G-actin-binding molecules affect F-actin formation can be utilized for analysis manipulation living cells. However, these obtained by extraction from...

Abstract DNA damage, which is constantly caused by exogenous and endogenous factors, subject to immediate repair processes; delays in these processes cause diseases. Here, we demonstrated that terahertz irradiation enhances the of double-strand break a non-thermal effect. The modulation damage provides non-invasive method with potential medical applications, such as prevention suppression diseases instability.

The high permittivity dielectric substrate having advantages in point of the miniaturization and matching with transmission wave was applied to NRD-guide Schottky barrier diode mount instead low one. Guided modes vertical strip line consisting were investigated eliminate undesired design choke circuit. consists circuit up converter. And experimental model proposed made. Its return loss measured compared calculated

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Continuous-wave THz radiation (0.10 and 0.28 THz) was irradiated to HeLa cells treated by bleomycin (BLM), the induction/repair of DNA damage observed visualizing γH2AX. The signal intensity γH2AX decreased during after BLM treatment when wave (250 mW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) sample, suggesting that enhances repair. This phenomenon not reproduced 0.10 continuous-wave irradiation (200 ), effect's frequency...

Time-lapse morphological analysis of human cells under THz irradiation shows inhibition cell division at cytokinesis. The contractile ring, which must disappear the end remained for 1 hour irradiation. This phenomenon was not reproduced by heating up sample, indicating that this is non-thermal effect We also observed induction filamentous actin, major component during (460 GHz and 280 GHz). These results are in good agreement with previous vitro experiments polymerization actin protein enhanced

This paper proposes a novel two-element active antenna for optical scanning beam in X-band. A MESFET the element works both as negative resistance and an optically controllable reactance. Laser illumination to one of elements causes shift its free-running frequency creates phase difference between oscillations two elements; therefore, radiation can be scanned. In experimental results, direction has been scanned by 26 degrees optically.