A5015484576- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Sodium Intake and Health
- Ion Transport and Channel Regulation
- Parathyroid Disorders and Treatments
Universidad de Valladolid
2020-2024
Instituto de Biomedicina y Genética Molecular de Valladolid
2020-2024
Consejo Superior de Investigaciones Científicas
2020-2024
Essential hypertension (HT) is a highly prevalent cardiovascular disease of unclear physiopathology. Pharmacological studies suggest that purinergic P2Y6 receptors (P2ry6) play important roles in function and may contribute to angiotensin II (AgtII) pathophysiological effects. Here, we tested the hypothesis functional coupling between P2ry6 AgtII mediates altered vascular reactivity HT. For this, multipronged approach was implemented using mesenteric smooth muscle cells (VSMCs) arteries from...
Abstract Chronic kidney disease (CKD) significantly increases cardiovascular risk. In advanced CKD stages, accumulation of toxic circulating metabolites and mineral metabolism alterations triggers vascular calcification, characterized by smooth muscle cell (VSMC) transdifferentiation loss the contractile phenotype. Phenotypic modulation VSMC occurs with significant changes in gene expression. Even though ion channels are an integral component function, effects uremia on channel remodeling...