A5049312255- Regulation of Appetite and Obesity
- Advanced Glycation End Products research
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Immune cells in cancer
- Eicosanoids and Hypertension Pharmacology
University of Gothenburg
2025
University of Amsterdam
2019
Amsterdam UMC Location University of Amsterdam
2019
Ghrelin, the endogenous ligand of growth hormone secretagogue receptor (GHSR), promotes food intake and other feeding behaviors, stimulates (GH) release from pituitary. Growth secretagogues (GHS), such as GHRP-6 MK-0677, are synthetic GHSR ligands that activate orexigenic neuropeptide Y neurons coexpress agouti-related peptide (AgRP) in arcuate nucleus hypothalamus when administered systemically. Systemic also GH humans rats. Thus, GHS ghrelin have therapeutic relevance patients who could...
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus that results in both tubular and glomerular injury. Low-grade inflammation oxidative stress are two mechanisms known to drive the progression DN. Nucleotide-binding leucine-rich repeat containing family member X1 (NLRX1) an innate immune receptor, uniquely located mitochondria, has been found regulate inflammatory responses dampen renal by regulating phosphorylation. For this reason, we investigated role NLRX1...