Isabelle L. Shepherd

ORCID: 0009-0004-8665-3957
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About
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Research Areas
  • Solid-state spectroscopy and crystallography
  • Quantum, superfluid, helium dynamics
  • Virus-based gene therapy research
  • Molecular Spectroscopy and Structure
  • Bacteriophages and microbial interactions
  • Viral gastroenteritis research and epidemiology

University of California, San Diego
1965-2024

Targeting proteins to specific subcellular destinations is essential in prokaryotes, eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their genomes a nucleus-like replication compartment composed of protein chimallin (ChmA) excludes ribosomes decouples transcription from translation. These selectively partition between phage nucleus bacterial cytoplasm. Currently, genes signals govern selective import into are unknown. Here, we identify two components this...

10.1073/pnas.2321190121 article EN cc-by Proceedings of the National Academy of Sciences 2024-04-30
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