A5057065063- Energy Load and Power Forecasting
- Grey System Theory Applications
- Dam Engineering and Safety
- Extracellular vesicles in disease
- Solar Radiation and Photovoltaics
- Environmental Impact and Sustainability
- Hydraulic flow and structures
- Phagocytosis and Immune Regulation
- Bacterial Infections and Vaccines
- Landslides and related hazards
- Rock Mechanics and Modeling
- Multi-Criteria Decision Making
- Risk and Safety Analysis
- Fuzzy Systems and Optimization
- Pneumonia and Respiratory Infections
- Cell Adhesion Molecules Research
- Diverse Interdisciplinary Research Innovations
- Inflammasome and immune disorders
- Hydrological Forecasting Using AI
- Adenosine and Purinergic Signaling
- Geotechnical Engineering and Analysis
- Antimicrobial Resistance in Staphylococcus
Second Affiliated Hospital of Zhejiang University
2021-2025
Zhejiang University of Finance and Economics
2024
Tianjin University
2021-2022
Methicillin-resistant Staphylococcus aureus (MRSA) infection, a major cause of hospital- and community-acquired pneumonia, still has high mortality rate. Extracellular vesicles (EVs), as crucial mediators intercellular communication, have significant impact on infectious diseases. However, the role EVs from alveolar macrophages (AMs) in MRSA pneumonia remains unclear. We report that AMs phagocytose release more mice with pneumonia. harboring phagocytosed exhibit proinflammatory effects...
Anti-PD-1 therapy, effective in patients with various advanced tumors, still encounters the challenge of insensitivity most patients. Here, we demonstrate that PD-L1 on tumor cell-derived extracellular vesicles (TEVs) is critical for anti-PD-1 therapy resistance. Reducing endogenous and transferring exogenous TEVs abrogates induces resistance, respectively. Notably, sorted onto via endosomal sorting complex required transport after ubiquitination by UBE4A gradually upregulated progression....
Abstract BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) pneumonia (MP) and MRSA bloodstream infections (MRSA-BSI) are relatively often described, but MP with secondary MRSA-BSI (termed as MP-BSI) is few reported. Herein, we attempted to investigate the clinical features, risk factors outcomes of MP-BSI in comparison alone.MethodsClinical data from patients was retrospectively collected. The cases were divided into groups alone MP-BSI. Determination independent for relied on...