A5041439533- Blood properties and coagulation
- Rheology and Fluid Dynamics Studies
- Wound Healing and Treatments
- Skin Protection and Aging
- Lymphatic System and Diseases
İzmir University of Economics
2024
UD-GenoMed (Hungary)
2013-2016
University of Debrecen
2016
TG2 (transglutaminase 2) is a calcium-dependent protein cross-linking enzyme which involved in variety of cellular processes. The threshold level calcium needed for endogenous and recombinant activity has been controversial, the former being more sensitive to than latter. In present study we address this question by identifying single amino acid change from conserved valine glycine at position 224 compared with sequence available genomic databases. Substituting residue Gly224 increased its...
Transglutaminase 2 (TG2) is a ubiquitously expressed multifunctional member of the transglutaminase enzyme family. It has been implicated to have roles in many physiological and pathological processes such as differentiation, apoptosis, signal transduction, adhesion migration, wound healing inflammation. Previous studies revealed that TG2 various intra- extra-cellular interacting partners, which contribute these processes. In present study, we identified molecular co-chaperone, DNAJA1, novel...
Abstract Objectives Transglutaminase 2 (TG2) is a unique protein having enzymatic and nonenzymatic functions that have been implicated in various biological pathological processes such as cell survival apoptosis, signaling, differentiation, adhesion migration, wound healing inflammation. As reported previous studies, TG2 expression activity increase by age suggesting possibly has roles cellular aging process. In this study, we aimed to explore the role of chronological skin through its...