A5041818873- Congenital Heart Disease Studies
- Cardiovascular and Diving-Related Complications
- Spectroscopy and Chemometric Analyses
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Advanced Statistical Methods and Models
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Radioactivity and Radon Measurements
- Analytical chemistry methods development
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac tumors and thrombi
- Tracheal and airway disorders
- Radioactive element chemistry and processing
- Cardiovascular Issues in Pregnancy
- Radiation Dose and Imaging
- Radioactive contamination and transfer
- Cardiovascular Effects of Exercise
Rambam Health Care Campus
2015-2024
Technion – Israel Institute of Technology
2006-2023
Meyer Children's Hospital
2007-2020
Rebecca Sieff Hospital
2020
Rappaport Family Institute for Research in the Medical Sciences
1998-2015
Universität Hamburg
2012
pfm medical (Germany)
2012
Haifa Medical Center
2012
Columbia University
2012
University of Haifa
2008
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTError propagation and figures of merit for quantification by solving matrix equationsAvraham. LorberCite this: Anal. Chem. 1986, 58, 6, 1167–1172Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 1986https://pubs.acs.org/doi/10.1021/ac00297a042https://doi.org/10.1021/ac00297a042research-articleACS PublicationsRequest reuse permissionsArticle Views1482Altmetric-Citations396LEARN ABOUT THESE...
Partial least squares (PLS) modeling is an algorithm for relating one or more dependent variables to two independent variables. As a regression procedure it apparently evolved from the method of principal components (PCR) using NIPALS algorithm, which similar power determining eigenvectors and eigenvalues matrix. This paper presents theoretical explanation PLS singular value decomposition method. The relation PCR demonstrated, shown be continuum possible solutions type. These other may give...
Background —Catecholaminergic polymorphic ventricular tachycardia (PVT) is characterized by episodes of syncope, seizures, or sudden death in response to physiological emotional stress. In 2 families with autosomal dominant inheritance, the disease gene was mapped chromosome 1q42-43. The objectives this study were characterize clinical features a Bedouin tribe from Israel and map gene. Methods Results —In tribe, 9 children (age, 7±4 years) 7 related have died suddenly during past decade, 12...
Abstract Sudden cardiac death caused by ventricular arrhythmias is a disastrous event, especially when it occurs in young individuals. Among the five major arrhythmogenic disorders occurring absence of structural heart disease catecholaminergic polymorphic tachycardia (CPVT), which highly lethal form inherited arrhythmias. Our study focuses on autosomal recessive missense mutation D307H calsequestrin gene, CASQ2. Because CASQ2 key player excitation contraction coupling, derangements...
Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they thought to contribute considerably sudden cardiac death and heart failure, especially in young children. Here, we describe 11 patients (5–13 years) with a predominant presentation (DCM). Metabolic investigations showed deficient protein N-glycosylation, leading diagnosis Congenital Disorders Glycosylation (CDG). Homozygosity mapping the consanguineous families locus two...
Background— The sinoatrial node is the main impulse-generating tissue in heart. Atrioventricular conduction block and arrhythmias caused by dysfunction are clinically important generally treated with electronic pacemakers. Although an excellent solution, pacemakers incorporate limitations that have stimulated research on biological pacing. To assess suitability of potential pacemakers, we tested hypothesis spontaneous electric activity human embryonic stem cell–derived cardiomyocytes...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia characterized by syncope and sudden death occurring during exercise or acute emotion. CPVT caused abnormal intracellular Ca(2+) handling resulting from mutations in the RyR2 CASQ2 genes. Because are involved different aspects of excitation-contraction coupling process, we hypothesized that these associated with functional Ca(²+) abnormalities. To test hypothesis generated induced Pluripotent Stem...
Background The Occlutech Figulla ASD device series (OFSO) shows an improved design for interventional closure, larger follow‐up are missing. Methods We retrospectively reviewed the feasibility, safety, implantation properties, results, and of closure using devices over a 5 year period by establishing multi‐institutional collaborative result registry with 16 contributing centers from 11 countries (IRFACODE). Results In 1315 patients all age groups (female 66.9%), successful (98%) was...
Background A significant percentage of patients with congenital heart disease surviving into adulthood will develop arrhythmias. These arrhythmias are associated an increased risk adverse events and death. We aimed to assess arrhythmia prevalence, factors, health care usage in a large national cohort adult disease. Methods Results Adults documented diagnosis disease, insured by Clalit Maccabi services between January 2007 December 2011, were included. assessed the associations subsequent...
To assess health-related quality of life (HRQoL), depressed mood, and self-esteem in adolescents with heart disease compare them age-matched healthy (control group).Ninety (aged 12 to 18 years congenital or acquired disease) 87 controls completed the HRQoL (TAAQOL-CHD), Center for Epidemiologic Studies Depression scale, Rosenberg questionnaires. Relevant medical details were collected. The patients their parents asked rate perceived severity disease.Adolescents severe reported higher levels...
Abstract Methods of multivariate calibration use models that relate spectral data or sensor array responses to the concentrations analytes. The goal is insure model can accurately estimate analyte in unknown samples not contained set. sensors channels (e.g. wavelengths) selected for incorporation model, as well step, are known have an effect on accuracy analysis samples. This work provides a fundamental treatment this and derives criteria optimal selection. Additionally, proof given...
The subject of analytical figures merit for tensorial calibration is critically reviewed. Tensorial derives its name from tensor algebra, which provides a classification methods depending on the complexity data obtained one chemical sample. Expressions net analyte signal, sensitivity (classical model formulation), inverse sensitivity' (inverse selectivity, signal-to-noise ratio and limit detection (in signal space) are proposed Nth-order (N≥2) that consistent with accepted zeroth-order...
The concentration of uranium in urine, hair, and nails due to continuous exposure through ingestion drinking water was studied. study population consisted 205 individuals living 134 different households southern Finland where is supplied from private drilled wells. selected include a broad range daily intake (0.03-2,775 microg d). content water, urine (overnight collection), hair determined by ICPMS. Uranium corrected for the matrix effects use thallium as an internal standard adjusted...
Abstract When arrays of non‐selective sensors or overlapping spectra are used for chemical analysis, multivariate calibration must be to relate the instrument responses individual analytes. Using a set carefully selected samples, mathematical model is constructed one more If this step successful, can predict concentrations these analytes in prospective samples. Previously, equations required estimate errors predicted concentrations, and from confidence intervals, were not available because...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFeatures of quantifying chemical composition from two-dimensional data array by the rank annihilation factor analysis methodAvraham. LorberCite this: Anal. Chem. 1985, 57, 12, 2395–2397Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/ac00289a052https://doi.org/10.1021/ac00289a052research-articleACS PublicationsRequest reuse permissionsArticle...
Paracetamol was reported to be effective for patent ductus arteriosus (PDA) closure. We present a case series of PDA closure by paracetamol in seven premature infants. During the treatment, blood levels did not exceed recommended analgesia and hyperthermia six tested None patients demonstrated significant disturbances liver function.