A5092964710- Mitochondrial Function and Pathology
- Metalloenzymes and iron-sulfur proteins
- Amyotrophic Lateral Sclerosis Research
- Genomics and Rare Diseases
- Medical Imaging and Pathology Studies
- Autophagy in Disease and Therapy
- Metabolism and Genetic Disorders
University Medical Center of the Johannes Gutenberg University Mainz
2023-2024
Johannes Gutenberg University Mainz
2023-2024
Institute for Molecular Medicine
2024
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in substantia nigra midbrain. Familial cases PD are often caused mutations PTEN-induced kinase 1 (PINK1) and ubiquitin ligase Parkin, both pivotal maintaining mitochondrial quality control. CISD1, a homodimeric iron-sulfur-binding protein, major target Parkin-mediated ubiquitination. We here discovered heightened propensity CISD1 to form dimers Pink1 mutant flies from PINK1 mutation patients. The dimer...
Abstract Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in substantia nigra midbrain. Familial cases PD are often caused mutations PTEN-induced kinase 1 (PINK1) and ubiquitin ligase Parkin, both pivotal maintaining mitochondrial quality control. CISD1, a homodimeric iron-sulfur-binding protein, major target Parkin-mediated ubiquitination. We here discovered heightened propensity CISD1 to form dimers Pink1 mutant flies from PINK1 mutation patients....