A5018075111- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Advanced Data Storage Technologies
- Algorithms and Data Compression
- RNA Interference and Gene Delivery
- Advanced Database Systems and Queries
- Parallel Computing and Optimization Techniques
- Animal Virus Infections Studies
- Polymer Surface Interaction Studies
- Ferroptosis and cancer prognosis
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Luminescence Properties of Advanced Materials
- Photoacoustic and Ultrasonic Imaging
- Cancer Immunotherapy and Biomarkers
- Inhalation and Respiratory Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Virus-based gene therapy research
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Thermal Regulation in Medicine
- Photopolymerization techniques and applications
ShanghaiTech University
2024
Shanghai Jiao Tong University
2023
Tianjin Medical University
2016-2020
Tianjin Medical University General Hospital
2015-2016
Abstract Nanothermometers enable the detection of temperature changes at microscopic scale, which is crucial for elucidating biological mechanisms and guiding treatment strategies. However, monitoring micron-scale structures in vivo using luminescent nanothermometers remains challenging, primarily due to severe scattering effect tissue that compromises imaging resolution. Herein, a lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm developed achieve...
Abstract The immune regulation of the lymphatic system, especially lymph node (LN), is great significance for treatment diseases and inhibition pathogenic organisms spreading in body. However, achieving precise spatiotemporal control cell activation LN vivo remains a challenge due to tissue depth off‐target effects. Furthermore, minimally invasive real‐time feedback methods monitor system are lacking. Here, focused ultrasound responsive immunomodulator loaded nanoplatform (FURIN) with...
Stomach adenocarcinoma (STAD) is one of the most common malignant tumors. The Janus kinases (JAKs) play a significant part in cellular biological process, inflammation, and immunity. roles JAKs STAD are still not systematically described.A series bioinformatics tools were used to clarify role STAD.JAK3/TYK2 levels significantly increased during subgroup analyses based on gender, tumor grade, cancer stages, nodal metastasis status. patients with high JAK3/TYK2 had poor overall survival,...
Abstract Macrophage engineering has emerged as a promising approach for modulating the anti‐tumor immune response in cancer therapy. However, spatiotemporal control and real‐time feedback of macrophage regulatory process is still challenging, leading to off‐targeting effect delayed efficacy monitoring therefore raising risk overactivation serious side effects. Herein, focused ultrasound responsive immunomodulator‐loaded optical nanoplatform (FUSION) designed achieve status reporting vivo....
Focused ultrasound (FUS) is a recognized tool that can be used clinically for the thermal ablation of tumors. However, excessive heat cause side effects on transmission path and normal tissues around tumor. To address issue, this work detected first time effect microscopic heating nanoparticles under action FUS through luminescence intensity ratio (LIR) lifetime temperature-responsive lanthanide-doped nanoparticles. When applied to tissue embedded with nanoparticles, increase in temperature...
Purpose: Thermal ablation has been used to manage liver malignancy. This study aimed assess histological changes in rat after microwave (MWA) and investigate whether thermal damage caused by MWA on surrounding tissue enhances the efficiency of gene transfer.Methods: was applied liver, pathological ultrastructural were evaluated. Green fluorescent protein (GFP) Renilla luciferase-expressing plasmids administered tissues direct injection. GFP expression analysed frozen sections using an...
BACKGROUNDS: Thermal ablation has been widely used to manage liver tumor. This study was designed determine histological change of rat after microwave ablation, investigate the effect on gene transfection. METHODS: In this study, applied liver, tissue demarcation evaluated. Green fluorescent protein (GFP) and Renilla luciferase-expressing plasmids were administrated by percutaneous or intravenous injection pre-ablation. The expression transgene in reactive inflammatory zone GFP determined...
Machine-generated data is rapidly growing and poses challenges for data-intensive systems, especially as the growth of outpaces storage space. To cope with issue, compression plays a critical role in engines, particularly applications, where high ratios efficient random access are essential. However, existing techniques tend to focus on general-purpose block approaches, but overlook inherent structure machine-generated hence result low-compression or limited lookup efficiency. address these...
Machine-generated data is rapidly growing and poses challenges for data-intensive systems, especially as the growth of outpaces storage space. To cope with issue, compression plays a critical role in engines, particularly applications, where high ratio efficient random access are essential. However, existing techniques tend to focus on general-purpose block approaches, but overlook inherent structure machine-generated hence result low ratios or limited lookup efficiency. address these...