A5080328345- Synthesis and biological activity
- Mesoporous Materials and Catalysis
- Cancer Treatment and Pharmacology
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- Dendrimers and Hyperbranched Polymers
Institute of Biochemical Physics NM Emanuel
2022
D. Mendeleyev University of Chemical Technology of Russia
2022
While histone deacetylase inhibitors, such as vorinostat, demonstrate a significant effect against hematological cancers, their application for solid tumor treatment is limited. However, there strong evidence that combinatorial administration of vorinostat and genotoxic agents (e.g., doxorubicin) enhances the antitumoral action both drugs tumors. We developed high‐performance liquid chromatography method simultaneous determination doxorubicin in polymeric nanoparticles designed to provide...
The objects of the present study are nanoparticles (NPs) based on a copolymer lactic and glycolic acids (PLGA), loaded with anticancer drug doxorubicin (DOX-NP) histone deacetylase inhibitor vorinostat (SAHA-NP) developed for breast cancer treatment [...]