A5062929567- Nanoparticle-Based Drug Delivery
- Intraocular Surgery and Lenses
- Cancer Treatment and Pharmacology
- Drug Transport and Resistance Mechanisms
- Medical and Biological Sciences
- Cancer therapeutics and mechanisms
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Chemical Reactions and Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Synthesis and biological activity
- Silymarin and Mushroom Poisoning
- Synthesis and Catalytic Reactions
- Chemical Reaction Mechanisms
- Carbon dioxide utilization in catalysis
- Biochemical effects in animals
- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Synthesis and bioactivity of alkaloids
- Enzyme function and inhibition
- Traumatic Ocular and Foreign Body Injuries
- Pharmacological Effects and Assays
- Phase-change materials and chalcogenides
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Plant-derived Lignans Synthesis and Bioactivity
Kurchatov Institute
2016-2023
Sechenov University
2013
Russian Academy of Natural Sciences
2000-2001
St Petersburg University
1997
Russian Academy of Sciences
1990
Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer Cremophor® EL, and its nonspecific accumulation greatly limit clinical application. Aim: To design paclitaxel-loaded copolymer of lactic glycolic acids nanoparticles decorated with alpha-fetoprotein third domain (rAFP3d-NP) to increase safety profile. Methods: rAFP3d-NP was obtained via carbodiimide technique. Results: The particles were characterized high loading content 5% size 280 nm. revealed...
Abstract The intramolecular Hbond strength in cis ‐enolic forms of β‐diketones was investigated. correlations between the 1 H hydroxyl proton shieldings and chemical shifts 13 C 17 O nuclei involved chelate ring, H/D isotope on latter resonances, were determined. An increase hydrogen bond leads to increasing values isotopic resonances. results obtained are compared with quantum calculations x‐ray measurements.
While histone deacetylase inhibitors, such as vorinostat, demonstrate a significant effect against hematological cancers, their application for solid tumor treatment is limited. However, there strong evidence that combinatorial administration of vorinostat and genotoxic agents (e.g., doxorubicin) enhances the antitumoral action both drugs tumors. We developed high‐performance liquid chromatography method simultaneous determination doxorubicin in polymeric nanoparticles designed to provide...
Folliculo-stellate cells are known as S-100 protein immunopositive of the anterior lobe pituitary gland which not secreting hormones and presumed to be organ specific stem adenohypophys. Their role in adaptation body stress remains unclear.To evaluate dynamics folliculo-stellate hormone-producing rats different age chronic exposure.Sprague-Dawley aged 1, 3, 6 12 months were exposed immersion immobilization stress. Histological section glands stained immunohistochemically with subsequent...
Актуальность. Одним из осложнений непроникающей синустрабекулэктомии (НСТЭ) является микроперфорация трабекуло-десцеметовой мембраны с блокадой ее корнем радужки и снижением гипотензивного эффекта. При этом эффективность YAG-лазерной десцеметогониопунктуры (ЛДГП) зависит как от сроков проведения, так состояния структур дренажной системы глаза. Поэтому изучение результатов НСТЭ разработка мер, направленных на повышение эффективности, являются актуальными. Цель.Анализ частоты блокады зоны...
Актуальность. УБМ является методом, позволяющим получить данные о до и послеоперационном состоянии хрусталика его связочном аппарате, а также положении ИОЛ в капсульном мешке (КМХ). Изучение новых моделей требует объективных данных параметрах КМХ нем, что делает данное исследование актуальным. Цель. Разработка анализ параметров для оценки положения объемозамещающей «Торсион» на основе УБМ. Материал методы. На сканограммах переднего отрезка глаза выполненных перпендикулярных меридианах после...
Using poly(lactic-co-glycolic) acid we developed a polymeric form of niclosamide (PFN) and investigated molecular mechanisms underlying its antitumor activity against human colorectal cancer cell lines (SW837, Caco-2, COLO 320 HSR). PFN was shown to be more cytotoxic cells less normal (human embryonic lung fibroblasts) as compared niclosamide. Both caused mitochondrial damage (evaluated decrease in rhodamine 123 accumulation) increased the levels reactive oxygen species, particularly...
Introduction . Docetaxel is widely used for cancer treatment. Actual issue newly developed polymer-based formulations applicability of current quality requirements. The technology polymeric forms, including gamma-sterilization, are differ from actual injections technology. In this study were PLGA-based particles with Docetaxel. main attention was directed to studying qualitative and quantitative content related impurities in forms during long-term storage gamma-sterilization comparison...
Introduction One of the perspective approaches to development anticancer chemotherapy drugs is use submicron vectorized delivery systems that increase selectivity action and reduce toxic side effects chemotherapy. A system docetaxel (DOC) loaded poly(lactide-co-glycolide) (PLGA) particles modified with folic acid dodecylamide (FAD) was developed (PLGA-DOC-FAD). The aim research a comparative toxicological study DOC-loaded standard solution form in acute subchronic experiments mice after...
Цель - выявить и изучить степень выраженности морфологических изменений структур коркового мозгового вещества почки на фоне смоделированной билатеральной модели ишемии-реперфузии. Материал методы. Эксперименты проведены 50 крысах-самцах линии Вистар массой 180-220 г. Моделирование ишемии-реперфузии проводилось путем наложения атравматичных зажимов обе почечные ножки 40 мин. Через 24 или 72 ч реперфузии проводили оценку структурных в корковом мозговом веществе с использованием гистологических...
The objects of the present study are nanoparticles (NPs) based on a copolymer lactic and glycolic acids (PLGA), loaded with anticancer drug doxorubicin (DOX-NP) histone deacetylase inhibitor vorinostat (SAHA-NP) developed for breast cancer treatment [...]