A5077621600- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Synthesis and Biological Evaluation
- Bacterial Infections and Vaccines
- Chemical Reaction Mechanisms
- Synthesis and biological activity
- Mycobacterium research and diagnosis
- Synthesis and Reactions of Organic Compounds
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pediatric Hepatobiliary Diseases and Treatments
- Ear Surgery and Otitis Media
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Cancer therapeutics and mechanisms
- Diagnosis and treatment of tuberculosis
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial Resistance in Staphylococcus
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Bacterial Identification and Susceptibility Testing
Wright State University
2002-2024
Grandview Medical Center
2019
Dayton VA Medical Center
1989-2017
St Michael's Hospital
2006
North Bristol NHS Trust
2005
Scripps Health
2001
Kettering Medical Center
1999
Cleveland Clinic
1994
United States Department of Veterans Affairs
1967-1988
University of Rochester
1980
Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed.We randomly assigned 124 patients with S. or without to receive 6 mg of daptomycin intravenously per kilogram body weight daily 122 initial low-dose gentamicin plus either an antistaphylococcal penicillin vancomycin. The primary efficacy end point was treatment success 42 days after the therapy.Forty-two therapy in modified intention-to-treat analysis, a successful outcome documented 53 120 who received as...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemotherapy of Experimental Tuberculosis. VIII. The Synthesis Acid Hydrazides, their Derivatives and Related Compounds1,2Harry L. Yale, Kathryn Losee, Joseph Martins, Mary Holsing, Frances M. Perry, Jack BernsteinCite this: J. Am. Chem. Soc. 1953, 75, 8, 1933–1942Publication Date (Print):April 1, 1953Publication History Published online1 May 2002Published inissue 1 April...
Part 1 Memorial aesthetics - Kant's Critique of Judgement: judgement without knowledge imperative beauty? the antinomy autonomous question reflective beauty and labour mourning indeterminacy metaphysics. 2 The genius being Heidegger's Origin Work Art: overcoming great art on exemplary genius, community praxis technology earth, world alterity polis as aesthetic alienation. 3 deconstructive sublime Derrida's Truth in Painting: art, history language painting truth there is interrupting...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalogs of Aspergillic Acid. IV. Substituted 2-Bromopyridine-N-oxides and Their Conversion to Cyclic Thiohydroxamic Acids1Elliott Shaw, Jack Bernstein, Kathryn Losee, W. A. LottCite this: J. Am. Chem. Soc. 1950, 72, 10, 4362–4364Publication Date (Print):October 1, 1950Publication History Published online1 May 2002Published inissue 1 October 1950https://pubs.acs.org/doi/10.1021/ja01166a008https://doi.org/10.1021/ja01166a008research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroxyurea. A New Type of Potential Antitumor Agent1Barbara Stearns, Kathryn A. Losee, and Jack BernsteinCite this: J. Med. Chem. 1963, 6, 2, 201Publication Date (Print):March 1, 1963Publication History Published online1 May 2002Published inissue 1 March 1963https://pubs.acs.org/doi/10.1021/jm00338a026https://doi.org/10.1021/jm00338a026research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations77LEARN ABOUT THESE...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemotherapy of Experimental Tuberculosis. III. The Synthesis Thiosemicarbazones and Related Compounds1,2Jack Bernstein, Harry L. Yale, Kathryn Losee, Mary Holsing, Joseph Martins, W. A. LottCite this: J. Am. Chem. Soc. 1951, 73, 3, 906–912Publication Date (Print):March 1, 1951Publication History Published online1 May 2002Published inissue 1 March...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTII. Derivatives of 2,6-Diaminopyridine1Jack Bernstein, Barbara Stearns, Elliott Shaw, and W. A. LottCite this: J. Am. Chem. Soc. 1947, 69, 5, 1151–1158Publication Date (Print):May 1, 1947Publication History Published online1 May 2002Published inissue 1 1947https://pubs.acs.org/doi/10.1021/ja01197a048https://doi.org/10.1021/ja01197a048research-articleACS PublicationsRequest reuse permissionsArticle Views1381Altmetric-Citations78LEARN ABOUT THESE...
Ribavirin was demonstrated to have an antiviral effect on respiratory syncytial virus in vitro. A 50% reduction plaque number observed at concentrations of 3 or 10 micrograms ribavirin per ml. This when the drug added as late 12 h postinfection. At greater than ml, size also noticeably decreased. similarly decreased infectious units released into culture supernatant. The be inversely related viral inoculum, although all above 3.2 ml visibly lessened cytopathic regardless inoculum. Cloning...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Properties of Some Substituted Benzyl Fluorides1Jack Bernstein, Jay S. Roth, William T. Miller Jr.Cite this: J. Am. Chem. Soc. 1948, 70, 7, 2310–2314Publication Date (Print):July 1, 1948Publication History Published online1 May 2002Published inissue 1 July 1948https://pubs.acs.org/doi/10.1021/ja01187a003https://doi.org/10.1021/ja01187a003research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTI. Derivatives of Aminopyridines1Jack Bernstein, Barbara Stearns, Martin Dexter, and W. A. LottCite this: J. Am. Chem. Soc. 1947, 69, 5, 1147–1150Publication Date (Print):May 1, 1947Publication History Published online1 May 2002Published inissue 1 1947https://pubs.acs.org/doi/10.1021/ja01197a047https://doi.org/10.1021/ja01197a047research-articleACS PublicationsRequest reuse permissionsArticle Views1177Altmetric-Citations30LEARN ABOUT THESE...
For fifteen years oral ciprofloxacin has been the standard treatment for malignant otitis externa, a sometimes fatal osteomyelitis of skull base usually caused by Pseudomonas aeruginosa . Resistance to is developing. Over 16-month period, we saw five cases where externa progressed, with development cranial nerve palsies in four cases, despite ciprofloxacin. Prolonged intravenous antibiotic therapy became necessary. One case was managed largely as an out-patient, but patients spent many weeks...
The proteins of respiratory syncytial virus have not been clearly identified due to the lability and difficulties in its purification. We pulse-labeled with [35S]methionine [35S]cysteine analyzed cell lysates by polyacrylamide gel electrophoresis. Five 35S-labeled viral ranging molecular weight from 21,000 73,000 (VP73, VP44, VP35, VP28, VP21) were easily discernable above background cellular proteins. Treatment infected cells 0.15 M NaCl before labeling suppressed host protein synthesis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT10-(3-Dimethylaminopropyl)-2-(Trifluoromethyl)-phenothiazine Hydrochloride (VESPRIN1) and Related Compounds. IHarry L. Yale, Francis Sowinski, Jack BernsteinCite this: J. Am. Chem. Soc. 1957, 79, 16, 4375–4379Publication Date (Print):August 1, 1957Publication History Published online1 May 2002Published inissue 1 August 1957https://pubs.acs.org/doi/10.1021/ja01573a037https://doi.org/10.1021/ja01573a037research-articleACS PublicationsRequest reuse...
A loading dose and short-term administration of oral ribavirin significantly improved symptoms signs influenza type or B infection in 25 patients. The antiviral effect was not significant. No adverse clinical effects significant laboratory values were observed. Oral treatment patients with might be possible ribavirin.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew class of semisynthetic penicillins and cephalosporins derived from D-2-(1,4-cyclohexadienyl)glycineJoseph E. Dolfini, Harold Applegate, Georges Bach, Basch, Jack Bernstein, Joseph Schwartz, Frank L. WeisenbornCite this: J. Med. Chem. 1971, 14, 2, 117–119Publication Date (Print):February 1, 1971Publication History Published online1 May 2002Published inissue 1 February...