A5021299610- Microbial Metabolic Engineering and Bioproduction
- Enzyme Structure and Function
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Fungal Plant Pathogen Control
- Phosphodiesterase function and regulation
- Plant Pathogens and Fungal Diseases
- Plant pathogens and resistance mechanisms
- Hemoglobinopathies and Related Disorders
Scripps Research Institute
2025
University of California, San Diego
2024
Shandong Academy of Agricultural Sciences
2013
University of Portland
2002
cAMP response element-binding protein (CREB)-regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning, and long-term memory formation through the regulation of neuronal activity-dependent gene expression, CRTC1 dysregulation is implicated Alzheimer’s disease (AD). Here, we show that increased S-nitrosylation (forming SNO-CRTC1), as seen cell-based, animal-based, human-induced pluripotent stem cell (hiPSC)-derived cerebrocortical neuron-based AD...
Sclerotinia sclerotiorum (Lib.) de Bary is a necrotrophic fungal pathogen causing diseases in wide range of plants, including oilseed rape (3). Substantial economic losses caused by S. have been reported the United States, Canada, Brazil, South Africa, Hungary, India, Nepal, and Japan (1). Application fungicides principal tool for controlling because lack high level host resistance. Dicarboximide such as dimethachlon widely used to control recent years China field isolates with reduced...
Immature erythroid cells have an exceptionally high capacity to synthesize haem that is, at least in part, the result of unique control iron metabolism these cells. In vast majority Fe released from endosomes must cross both outer and inner mitochondrial membranes reach ferrochelatase, which inserts into protoporphyrin IX. Based on fact is specifically targeted mitochondria, we proposed a transient mitochondria-endosome interaction involved transfer ferrochelatase [Ponka (1997) Blood 89,...