A5101820266- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Conducting polymers and applications
- Graphene and Nanomaterials Applications
- Advanced Sensor and Energy Harvesting Materials
- Electrochemical sensors and biosensors
- Cancer Research and Treatments
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Click Chemistry and Applications
- Advanced Drug Delivery Systems
- Supercapacitor Materials and Fabrication
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- 3D Printing in Biomedical Research
- Organic Electronics and Photovoltaics
- Drug Solubulity and Delivery Systems
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Nanomaterials in Catalysis
- Peptidase Inhibition and Analysis
- Analytical Chemistry and Sensors
- Neonatal and fetal brain pathology
- Polymer Surface Interaction Studies
- Sulfur Compounds in Biology
- Cancer Treatment and Pharmacology
Nankai University
2022-2024
State Key Laboratory of Medicinal Chemical Biology
2022-2024
Shanxi University
2023
Zaozhuang Municipal Hospital
2021-2022
East China University of Science and Technology
2007-2012
Abstract Nanomedicine has shown promising therapeutic potential in cancer treatment, with clinically approved formulations such as Doxil® and Abraxane® already providing tangible benefits to patients. However, challenges low targeting efficiency poor tumor penetration limit its application. Bacteria have emerged drug delivery carriers due their capacity for autonomous navigation deep into hypoxic parenchyma. Therefore, utilizing bacteria nanomedicine can partially overcome the limitations of...
The desmoplastic stroma imposes a fatal physical delivery barrier in pancreatic ductal adenocarcinoma (PDAC) therapy. Deconstructing the components hence predominates stroma-targeting approaches, but conflicting outcomes have sometimes occurred due to multifaceted nature of stroma. Here, we constructed two sub-20-nm nanomedicines based on so-called "next-wave" antifibrotic halofuginone (HF) and tumoricidal paclitaxel (PTX) for enhanced PDAC chemotherapy. This was achieved by coassembling...
The maintenance of robust ratiometric loading dual therapeutic agents and fine-tuning release kinetics for consistent in vitro vivo optimization combination effects is vital discovering new anticancer drug combinations remains challenging. Smart nanomedicine strategies have been investigated this purpose, but most the reported focus either on delivery or unimodal sequential two different agents, which hampers effective effects. Herein we report a system based nanoformulated mutual prodrugs...
Traumatic optic neuropathy (TON) is a severe condition characterized by retinal ganglion cell (RGC) death, often leading to irreversible vision loss, and the death of RGCs closely associated with oxidative stress. Unfortunately, effective treatment options for TON are lacking. To address this, catalase (CAT) encapsulated in tannic acid (TA)/poly(ethylenimine)-crosslinked hollow nanoreactor (CAT@PTP), which exhibited enhanced anchoring retina due TA-collagen adhesion. The antioxidative...
This study aimed to investigate the role and mechanism of long non-coding RNA maternally expressed gene 3 (MEG3) in cognitive dysfunction induced by isoflurane (ISO). Morrier water maze analysis was performed evaluate function rats. Modified modified neurological severity score (mNSS) scores were assessed for damage. The levels MEG3 hippocampal tissues rats neuron cell lines HT22 examined reverse transcription-quantitative polymerase chain reaction (qRT-PCR). Moreover, viability apoptosis...
Abstract The melt‐processable polyaniline nanofibers doped with superfluous dodecylbenzenesulfonic acid (PANI‐DBSA) were synthesized using the interfacial polymerization and thermal doping technique. Conducting composites composed of PANI‐DBSA nanofibers, low‐density polyethylene (LDPE), ethylene‐acrylic copolymer (EAA) as compatibilizer prepared by melt processing. effects on electrical conductivity, mechanical properties, morphological structure investigated. As a result, conducting had...