A5042452912- Hippo pathway signaling and YAP/TAZ
- Neuroblastoma Research and Treatments
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Cancer-related molecular mechanisms research
Quantitative BioSciences
2024
Second Affiliated Hospital of Zhejiang University
2020
Jingzhou Central Hospital
2020
Abstract Many tumor types harbor alterations in the Hippo pathway, including mesothelioma, where a high percentage of cases are considered YAP1/TEAD dependent. Identification autopalmitoylation sites hydrophobic palmitate pocket TEADs, which may be necessary for YAP1 protein interactions, has enabled modern drug discovery platforms to generate compounds that allosterically inhibit complex formation and transcriptional activity. We report characterization novel inhibitor MRK-A from an aryl...
Long non-coding RNAs (lncRNAs) have been demonstrated to act as essential regulators in the growth and progression of neuroblastoma.In present research, high expression lncRNA small nucleolar RNA host gene 4 (SNHG4) neuroblastoma was tested via quantitative reverse transcription-polymerase chain reaction (qRT-PCR), then function SNHG4 explored verified by CCK-8 assay, EdU cell cycle apoptosis test, wound healing invasion test lines.It discovered that exhibited tissues lines, associated with...
MicroRNA (miR)-103a-3p has been shown to be involved in the development and progression of several types cancer.However, role miR-103a-3p thyroid cancer remains unclear.This study investigated effects on biological characteristics cells related mechanisms.In present study, we found that expression was increased tissues compared non-cancerous tissues.Additionally, cell lines (TPC-1, SW579, BHT101, K1) markedly higher than human line (Nthy-ori3-1).Silencing obviously inhibited proliferation,...
<p>Characterization of HGF impact on MRK-A activity.</p>
<p>In vivo pathway analysis after MRK-A treatment.</p>
<p>Supplementary/extended materials and methods</p>
<p>In vitro characterization of MRK-A.</p>
<div>Abstract<p>Many tumor types harbor alterations in the Hippo pathway, including mesothelioma, where a high percentage of cases are considered YAP1/TEAD dependent. Identification autopalmitoylation sites hydrophobic palmitate pocket TEADs, which may be necessary for YAP1 protein interactions, has enabled modern drug discovery platforms to generate compounds that allosterically inhibit complex formation and transcriptional activity. We report characterization novel inhibitor...
<p>Characterization of HGF impact on MRK-A activity.</p>
<p>MRK-A combination with immune checkpoint blockade.</p>
<p>Pathway analysis after MRK-A treatment in vitro and vivo characterization.</p>
<p>In vitro characterization of MRK-A.</p>
<p>In vivo pathway analysis after MRK-A treatment.</p>
<p>Supplementary/extended materials and methods</p>
<p>In vitro RNA-Seq characterization of MRK-A.</p>
<p>In vitro RNA-Seq characterization of MRK-A.</p>
<p>Pathway analysis after MRK-A treatment in vitro and vivo characterization.</p>
<p>MRK-A combination with immune checkpoint blockade.</p>
<div>Abstract<p>Many tumor types harbor alterations in the Hippo pathway, including mesothelioma, where a high percentage of cases are considered YAP1/TEAD dependent. Identification autopalmitoylation sites hydrophobic palmitate pocket TEADs, which may be necessary for YAP1 protein interactions, has enabled modern drug discovery platforms to generate compounds that allosterically inhibit complex formation and transcriptional activity. We report characterization novel inhibitor...