A5067876504- Hydrogels: synthesis, properties, applications
- Cellular Mechanics and Interactions
- Supramolecular Self-Assembly in Materials
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- Cancer Treatment and Pharmacology
- Advanced Sensor and Energy Harvesting Materials
- Breast Cancer Treatment Studies
- Polymer Surface Interaction Studies
- Silk-based biomaterials and applications
- Biochemical and Structural Characterization
- Acoustic Wave Resonator Technologies
- Advanced Power Amplifier Design
- Tumors and Oncological Cases
- Advanced Battery Technologies Research
- Cancer Immunotherapy and Biomarkers
- Electrostatics and Colloid Interactions
- RNA regulation and disease
- Histone Deacetylase Inhibitors Research
- Fire Detection and Safety Systems
- Nanoparticle-Based Drug Delivery
- Hippo pathway signaling and YAP/TAZ
- Laser and Thermal Forming Techniques
- HER2/EGFR in Cancer Research
Collaborative Innovation Center of Advanced Microstructures
2018-2025
Nanjing University
2016-2025
Nantong University
2021-2025
Northwestern Polytechnical University
2024
First Affiliated Hospital of Bengbu Medical College
2024
Jiangsu Cancer Hospital
2009-2023
Nanjing Medical University
2023
Hubei University of Medicine
2022
Shandong University of Science and Technology
2021
Istituto di Scienze Marine del Consiglio Nazionale delle Ricerche
2021
A strong, tough, and fast-recovery hydrogel is engineered by cooperative interactions between histidine-rich peptides Zn 2+ .
Abstract Hydrogels are promising soft materials as tissue engineering scaffolds, stretchable sensors, and robotics. Yet, it remains challenging to develop synthetic hydrogels with mechanical stability durability similar those of the connective tissues. Many necessary properties, such high strength, toughness, rapid recovery, fatigue resistance, generally cannot be established together using conventional polymer networks. Here we present a type comprising hierarchical structures picot fibres...
Mechanical properties of hydrogels are critical for their applications as articular cartilage regeneration scaffolds, because they provide not only the mechanical support, but also cues essential to maintain phenotype cartilage‐forming cells. Inspired by microscopic architecture natural cartilage, here engineering a novel double‐network hydrogel with interconnected polymer‐supramolecular polymer (PS‐DN gel) is reported. The network made polyacrylamide and supramolecular comprises kind...
Amino acid crystals have emerged as promising piezoelectric materials for biodegradable and biocompatible sensors; however, their relatively low coefficients constrain practical applications. Here, we introduce a fluoro‐substitution strategy to overcome this limitation enhance the performance of amino crystals. Specifically, substituted hydrogen atoms on aromatic rings L‐tryptophan, L‐phenylalanine, N‐Cbz‐L‐phenylalanine with fluorine, resulting in significantly elevated coefficients....
Abstract Biological load‐bearing tissues are strong, tough, and recoverable under periodic mechanical loads. However, such features have rarely been achieved simultaneously in the same synthetic hydrogels. Here, we use a force‐coupled enzymatic reaction to tune strong covalent peptide linkage reversible bond. Based on this concept engineered double network hydrogels that combine high strength recovery Specifically, found ligase, sortase A, can promote proteolysis of peptides force. The bond...
Amino acid crystals have emerged as promising piezoelectric materials for biodegradable and biocompatible sensors; however, their relatively low coefficients constrain practical applications. Here, we introduce a fluoro‐substitution strategy to overcome this limitation enhance the performance of amino crystals. Specifically, substituted hydrogen atoms on aromatic rings L‐tryptophan, L‐phenylalanine, N‐Cbz‐L‐phenylalanine with fluorine, resulting in significantly elevated coefficients....
Abstract MXenes hold great promise for flexible sensors due to their outstanding electrical and mechanical properties. However, practical application in aqueous environments is often compromised by oxidation susceptibility. Here, epigallocatechin gallate (EGCG), a naturally derived compound introduced, as protective coating Ti₃C₂T x MXene nanosheets. The catechol groups EGCG form strong hydrogen bonds with MXene, significantly enhancing its resistance up 40 days. By incorporating EGCG‐coated...
Hydrogels with dynamic mechanical properties are of special interest in the field tissue engineering and drug delivery. However, it remains challenging to tailor response hydrogels simultaneously meet diverse application needs. Here, we report a hetero-coiled-coil complex cross-linked protein hydrogel exhibiting unusual multiple energy dissipation modes tunable response. Such unique features confer on responsiveness stimuli broad range frequencies. Therefore, injectable due their...
Hypocholesterolemia is a risk factor for morbidity and mortality in older people. We have hypothesized that hypocholesterolemia people due to the chronic effect of proinflammatory cytokines on lipoprotein metabolism.To test effects administration interleukin-6 (IL-6) levels middle-aged old rhesus monkeys, five monkeys received subcutaneous injection recombinant human IL-6 (15 micrograms/kg) 28 days. Lipid, apolipoprotein, albumin were measured at 0, 28, 42 days after injection.Total HDL...
There is growing evidence that the mechanical properties of extracellular matrices (ECMs), including elasticity and stress-relaxation, greatly influence function form residing cells. However, effects stress-relaxation are often correlated, making study effect on cellular behaviors difficult. Here, we designed a hybrid network hydrogel with controllable gradient constant elasticity. The crosslinked by covalent bonds dynamic peptide-metal ion coordination interactions. controlled spatially...
To assess the efficacy of pirfenidone combined with PD-L1 inhibitor for treatment bladder cancer in a mouse model and its effect on tumor immune microenvironment modulation.
MicroRNA (miR)-103a-3p has been shown to be involved in the development and progression of several types cancer.However, role miR-103a-3p thyroid cancer remains unclear.This study investigated effects on biological characteristics cells related mechanisms.In present study, we found that expression was increased tissues compared non-cancerous tissues.Additionally, cell lines (TPC-1, SW579, BHT101, K1) markedly higher than human line (Nthy-ori3-1).Silencing obviously inhibited proliferation,...
ABSTRACT Objectives The identification of structural variants and single‐nucleotide is essential in finding molecular etiologies monogenic genetic disorders. Whole‐genome sequencing (WGS) becoming more widespread disease diagnosis. However, data on its clinical utility remain limited prenatal practice. We aimed to expand our understanding implementing WGS the diagnosis fetal anomalies. Methods employed trio with a minimum coverage 40× MGI DNBSEQ‐T7 platform cohort 17 fetuses presenting...
Polymer network structures can affect the crosslinkers through differential swelling forces acting on crosslinkers, and change dynamic response of hydrogels.
e15653 Background: To determine the overall survival for patients with metastatic pancreatic cancer treated lapatinib and gemcitabine. Methods: Patients received lapatinib, 1,500 mg/day, Gemcitabine, 1 gm/m 2 /week 3 weeks followed by week off, until disease progression. This multicenter phase II study was planned to enter 125 evaluate if treatment regimen could achieve a 1-year of 30% median 7 months. An additional subset 20 were receive months single agent Results: At 6 month analysis,...
Abstract Biological load‐bearing tissues are strong, tough, and recoverable under periodic mechanical loads. However, such features have rarely been achieved simultaneously in the same synthetic hydrogels. Here, we use a force‐coupled enzymatic reaction to tune strong covalent peptide linkage reversible bond. Based on this concept engineered double network hydrogels that combine high strength recovery Specifically, found ligase, sortase A, can promote proteolysis of peptides force. The bond...