A5032427883- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Zebrafish Biomedical Research Applications
- Genetic Neurodegenerative Diseases
- Pharmacogenetics and Drug Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- Historical and Modern Theater Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Early Modern Spanish Literature
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- RNA Research and Splicing
Institute of Cytology and Genetics
2022-2025
Institute of Art History
2023
Tryptophan hydroxylase 2 (TPH2) hydroxylates L-tryptophan to L-5-hydroxy tryptophan-the key step of 5-HT synthesis in the mammalian brain. Some mutations human hTPH2 gene are associated with psychopathologies and resistance antidepressant therapy. The C1473G polymorphism mouse Tph2 decreases TPH2 activity In present paper, B6-1473C B6-1473G congenic mice that were different only C > G substitution used. molecular mechanism decrease mutant enzyme some physiological behavioral traits affected...
Parkinson’s disease (PD) is the most common age-related movement disorder characterized by progressive loss of nigrostriatal dopaminergic neurons. To date, PD treatment strategies are mostly based on dopamine replacement medicines, which can alleviate motor symptoms but do not slow down progression neurodegeneration. Thus, there a need for disease-modifying therapies. The aim this work was to evaluate neuroprotective effects novel compound PA96 neurons in vivo and vitro, assess its ability...
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme of serotonin (5-HT) synthesis in mammalian brain. The 1473G mutation Tph2 gene decreases TPH2 activity mouse brain by twofold. (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one (BH4) a pharmacological chaperone for aromatic amino acid hydroxylases. In present study, effects BH4 on mutant C1473G were investigated vitro vivo. increased thermal stability (T50 value) wild-type molecules. At same...
The annual turquoise killifish (Nothobranchius furzeri) is a laboratory model organism for neuroscience of aging. In the present study, we investigated first time levels serotonin and its main metabolite, 5-hydroxyindoleacetic acid, as well activities key enzymes synthesis, tryptophan hydroxylases, degradation, monoamine oxidase, in brains 2-, 4- 7-month-old male female N. furzeri. marked effect age on body mass level serotonin, hydroxylases oxidase brain were revealed. decreased males...
The dopamine brain system is involved in the regulation of various physiological processes and behavioral responses, including social behavior. It was shown rodents that prolonged isolation can lead to changes parameters neurochemical parameters, but these data remain unclear. In this work, we studied effects on behavior state male C57Bl/6 mice. Animals experimental group from age 40 - 42 days were kept individually separate cages for six weeks, while mice control in-group conditions....
Tryptophan hydroxylases 1 and 2 (TPH1 TPH2) play a key role in the synthesis of serotonin (5-HT), hormone neurotransmitter, peripheral organs brain, respectively. The main aim this study was to clarify distribution mRNA Tph1 Tph2 genes brain structures under normal conditions after inflammation. experiments were carried out on young (4 weeks old) male C57BL/6 mice. animals divided into three groups: intact, control, injected ip with saline, mg/kg bacterial lipopolysaccharide (LPS). Markers...
This review of P. Calderón’s collected plays focuses on a stylistic analysis Natalya Vankhanen’s new Russian translation Life Is Dream [ La vida es sueño ], considered the crowning glory Spanish baroque theatre, as well its interpretation and dramatic nuances translated play in stage version Moscowbased Elektrotheatre Stanislavsky, including their effect production’s portrayal Segismundo. The reviewer stresses translator’s unique, authorial view poetic text. It results, firstly,...
Prolonged social isolation can disrupt the functional activity of serotonin (5-HT) neurotransmitter system and neurotrophic support brain, activate neuroinflammatory processes, cause various behavioral disorders [1]. On contrary, pro-inflammatory cytokine, specifically tumor necrosis factor (TNF), affects synthesis expression neurotrophins in brain [2]. Additionally, TNF gene knockout alters severity depression-like behavior cognitive functions rodents [3]. The objective this study was to...