A5024487346- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Peptides and Activities
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Diabetes Management and Research
- vaccines and immunoinformatics approaches
- interferon and immune responses
California Institute of Technology
2023-2025
Nanoparticle vaccines displaying combinations of SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) could protect against SARS-CoV-2 variants and spillover zoonotic sarbecoviruses into humans. Using a computational approach, we designed RBDs selected 7 natural sarbecovirus RBDs, each predicted to fold properly abrogate antibody responses variable epitopes. were attached 60-mer nanoparticles make immunogens two (mosaic-2COMs), five (mosaic-5COM), or seven (mosaic-7COM)...
The transplantation of pancreatic endocrine islet cells from cadaveric donors is a promising treatment for type 1 diabetes (T1D), which chronic autoimmune disease that affects approximately nine million people worldwide. However, the demand donor islets outstrips supply. This problem could be solved by differentiating stem and progenitor to cells. many current culture methods used coax differentiate into require Matrigel, matrix composed extracellular (ECM) proteins secreted mouse sarcoma...
1Using computational methods, we designed 60-mer nanoparticles displaying SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) by (