A5022131571- Microtubule and mitosis dynamics
- Protist diversity and phylogeny
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Antifungal resistance and susceptibility
- IL-33, ST2, and ILC Pathways
- Genetic and Kidney Cyst Diseases
- Reproductive Biology and Fertility
- Mycotoxins in Agriculture and Food
- Research on Leishmaniasis Studies
- Photosynthetic Processes and Mechanisms
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Earthquake Detection and Analysis
- Hedgehog Signaling Pathway Studies
- Lipid metabolism and biosynthesis
- Computational Physics and Python Applications
- Respiratory and Cough-Related Research
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- Sinusitis and nasal conditions
- Cultural Insights and Digital Impacts
Centre National d'Études Spatiales
2024
Université Paris Cité
1995-2007
Laboratoire de Génétique Cellulaire
2005
National Institute of Environmental Health Sciences
2001
North Carolina State University
2001
Galderma (France)
2001
Sorbonne Université
2001
Centre National de la Recherche Scientifique
1989
In animal models of asthma, interleukin-13 (IL-13) induces goblet cell metaplasia, eosinophil infiltration the bronchial mucosa, and hyperreactivity, but basis its effects on airway epithelia remain unknown. Lesions epithelial barrier, frequently observed in asthma other chronic lung inflammatory diseases, are repaired through proliferation, migration, differentiation cells. An process may then, therefore, influence regeneration. We have thus investigated effect IL-13 mucociliary human nasal...
In animal models of asthma, interleukin-13 (IL-13) induces goblet cell metaplasia, eosinophil infiltration the bronchial mucosa, and hyperreactivity, but basis its effects on airway epithelia remain unknown. Lesions epithelial barrier, frequently observed in asthma other chronic lung inflammatory diseases, are repaired through proliferation, migration, differentiation cells. An process may then, therefore, influence regeneration. We have thus investigated effect IL-13 mucociliary human nasal...
ABSTRACT Centrin protein is an ubiquitously expressed cytoskeletal component and a member of the EF-hand superfamily calcium-binding proteins. It was first discovered in flagellar apparatus unicellular green algae where it involved contraction Ca2+-sensitive structures. associated with centrosome-related structures such as spindle pole body yeast, centriole/basal bodies ciliated cells. Three centrin genes have been cloned human In this work, we performed comparative biochemical functional...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
ABSTRACT Tubulins are the major proteins within centriolar and axonemal structures. In all cell types studied so far, numerous α- β-tubulin isoforms generated both by expression of a multigenic family various post-translational modifications. We have developed primary culture human nasal epithelial cells where ciliated differentiation process has been observed quantified. used this system to study several properties concerning polyglutamylation polyglycylation tubulin. GT335, monoclonal...
Abstract Suppressor of fused, Su(fu), was identified as a semi-dominant suppressor the putative serine/threonine kinase encoded by segment polarity gene fused in Drosophila melanogaster. The amorphic Su(fu) mutation is viable, shows maternal effect and displays no phenotype itself. mutations are often found associated to karmoisin (kar) but two complementation groups can be clearly identified. By using differential hybridization screening method, we have cloned region chromosomal...
A major innate immune response to inhaled conidia of the opportunistic pathogen Aspergillus fumigatus (Af) is synthesis pro-inflammatory cytokines, which include tumour necrosis factor (TNF)-alpha, a known inducer apoptosis. Modulation host cell apoptosis has been reported be one mechanisms whereby pathogens overcome defences. Our study was designed investigate whether or not Af could modulate induced by TNF-alpha staurosporine (STS). Exposure epithelial cells treated these inducers and...
Retinoids play a critical role in the maintenance of mucociliary phenotype epithelial cells upper respiratory tract. To determine retinoic acid receptors (RARs) regulation differentiation, we tested effect synthetic retinoids CD336, CD2019, and CD666, selective agonists for RARalpha, RARbeta, RARgamma, respectively, during differentiation human nasal (HNE) vitro. Using glutamylated tubulin transglutaminase I (Tg I) as markers ciliated cell squamous showed that (RA) stimulated and, parallel,...
Conclusions. Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal cells. Considering that the ligand is viral dsRNA, this result good accordance previous reports demonstrating airway have resistance to rhinovirus infection. Objective. use immune responses combat inspired potential pathogens. TLRs recognize pathogen-associated molecular...
The present study aims to investigate the role of p73 in response cisplatin treatment p53 wild-type neuroblastoma SH-SY5Y cells. Results showed that induced a dose-dependent up-regulation p53, p73, and number p53-responsive genes. Interestingly, endogenous Δexon2p73-expression was down-regulated by treatment. Neither p21 nor GADD45 induction observed p53-deficient Lan-1 cells, although TAp73 expression markedly induced. In presence cisplatin, exogenous overexpression cells without altering...
When a cloud of plasma from corona mass ejection hits the Earth's magnetosphere, rapid perturbation magnetopause current systems occurs. It generates signal that is detected worldwide by ground magnetic observatories in form Sudden Storm Commencement (SSC). This has an amplitude approximatively 20 nT but similar to signals generated other phenomena. Existing lists SSCs had been set human inspection time series. We have implemented and tested method automatically detect SSC events using...