A5042140533- MicroRNA in disease regulation
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Ginger and Zingiberaceae research
- Phagocytosis and Immune Regulation
- FOXO transcription factor regulation
The First People's Hospital of Shunde
2019-2023
Southern Medical University
2019-2023
Misregulated microRNA network has been emerging as the main regulator in non-alcoholic fatty liver disease (NAFLD). The deregulation of miR-122-5p is associated with disease. However, specific role and molecular mechanism NAFLD remain unclear. In this study, we have reported that high-fat diet (HFD) or palmitic acid (PA) significantly upregulated hepatic expression vivo vitro. Inhibition suppressed accumulation-induced inflammation lipids oxidative stress damage PA-treated L02 cells...
Background Accumulating evidence showed that the expression of miR-122 was abnormal in NAFLD patients; however, role on lipid accumulation and inflammation is not clear.Methods RT-qPCR applied to detect levels pro-inflammatory cytokines following transfected with inhibitor or treated oleic acid (OA). Detection performed by triglyceride content test oil red o staining assay. Western blotting protein TLR7, TLR4, MyD88 NF-κBp65.Results We found OA promoted secretion activated...
To explore the effect and potential mechanism of dihydroartemisinin (DHA) on metabolism-related fatty liver disease.A metabolic associated disease (MAFLD) mice model was induced with continuous supplies high-fat diet. DHA intraperitoneally injected into mice. The weight monitored. concentrations total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density (HDL) in serum were detected by an automatic biochemical analyzer. tissues stained hematoxylin eosin oil red O....