A5103104261- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Synthesis of heterocyclic compounds
- Ferrocene Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Synthesis and Biological Evaluation
- Pancreatitis Pathology and Treatment
- Toxin Mechanisms and Immunotoxins
- Pharmacogenetics and Drug Metabolism
- Thyroid and Parathyroid Surgery
- Antibiotics Pharmacokinetics and Efficacy
- Veterinary medicine and infectious diseases
- Essential Oils and Antimicrobial Activity
- HIV Research and Treatment
- Chromatography in Natural Products
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- Synthesis and Characterization of Pyrroles
- Gallbladder and Bile Duct Disorders
- Berberine and alkaloids research
- Crystal structures of chemical compounds
Peking University
2025
Peking University Third Hospital
2025
Jiangsu Academy of Agricultural Sciences
2014-2023
Yangzhou University
2008-2023
The First People's Hospital of Shunde
2015-2023
Southern Medical University
2014-2023
Sichuan University
2019
West China Hospital of Sichuan University
2019
Nanfang Hospital
2014
Nanjing Agricultural University
2007-2009
Misregulated microRNA network has been emerging as the main regulator in non-alcoholic fatty liver disease (NAFLD). The deregulation of miR-122-5p is associated with disease. However, specific role and molecular mechanism NAFLD remain unclear. In this study, we have reported that high-fat diet (HFD) or palmitic acid (PA) significantly upregulated hepatic expression vivo vitro. Inhibition suppressed accumulation-induced inflammation lipids oxidative stress damage PA-treated L02 cells...
OATP1B, P‐gp, BCRP, and CYP3A are the most contributing drug‐metabolizing enzymes or transporters (DMETs) for commonly prescribed medication. Their activities may change in end‐stage renal disease (ESRD) patients with large inter‐individual variabilities (IIVs), leading to altered substrate drug exposure ultimately elevated safety risk. However, changing extent indictive influencing factors not quantified so far. Here, a microdose cocktail regimen containing five sensitive drugs...
The aim of the research was to investigate anti-inflammatory mechanism Pulsatillae Decoction (PD), levels interleukin (IL)-6, IL-8, E-selectin, and thromboxane B2 (TXB2) secreted by cultured rat intestinal microvascular endothelial cells (RIMECs) were determined after treatment with its active ingredients, namely anemoside B4, anemonin, berberine, jatrorrhizine, palmatine, aesculin, esculetin. RIMECs challenged 1 μg/mL lipopolysaccharide (LPS) for 3 h, then treated each seven ingredients at...
Streptococcus suis serotype 2 (SS2) is an important swine and human pathogen responsible for septicemia meningitis. The bacterial homologues of eukaryotic-type serine/threonine kinases (ESTKs) have been reported to play critical roles in various cellular processes. To investigate the role STK SS2, isogenic stk mutant strain (Δstk) a complemented (CΔstk) were constructed. Δstk showed significant decrease adherence HEp-2 cells, compared with wild-type strain, reduced survival ratio whole...
Background Accumulating evidence showed that the expression of miR-122 was abnormal in NAFLD patients; however, role on lipid accumulation and inflammation is not clear.Methods RT-qPCR applied to detect levels pro-inflammatory cytokines following transfected with inhibitor or treated oleic acid (OA). Detection performed by triglyceride content test oil red o staining assay. Western blotting protein TLR7, TLR4, MyD88 NF-κBp65.Results We found OA promoted secretion activated...
To explore the effect and potential mechanism of dihydroartemisinin (DHA) on metabolism-related fatty liver disease.A metabolic associated disease (MAFLD) mice model was induced with continuous supplies high-fat diet. DHA intraperitoneally injected into mice. The weight monitored. concentrations total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density (HDL) in serum were detected by an automatic biochemical analyzer. tissues stained hematoxylin eosin oil red O....
Reaction of 1,2-bis(2-aminophenoxy)ethane with benzoylacetone and ferrocenoylacetone yields tetradentate enaminones H2L1 H2L2, respectively. copper acetate two affords the corresponding complexes 1 2, which are formulated as [L1Cu] [L2Cu], The structures H2L1, H2L2 have been determined by single-crystal X-ray crystallography. Enaminone crystallizes Z = 4 in space group C2/c, molecule lies on a C 2 axis. P21/c, possesses symmetric center. For complex 1, P is bianionic donor via carbonyl...
Objective To evaluate catheterization in pancreatic duct before endoscopic papillary balloon dilation (EPBD) to prevent pancreatitis after EPBD. Methods Forty-three patients with normal serum amylase levels, diagnosed as having bile stones, underwent EPBD. Twenty-three were assigned experimental group, where catheters(ERCP imaging tube)were placed EPBD, then the was expanded 10 mm. Twenty control group eight-millimeter-diameter used remove stones. The levels 6 hours and 24 incidence...
Objective To investigate the effect of EST and EPBD on gallbladder function. Methods Fifty-eight patients who underwent common bile duct lithotomy were divided into three groups, major incision group （21）, minor （20） endoscopic papillary balloon dilation （17）. Twenty healthy people involved as control group. The hepatobiliary dynamic imaging was used to evaluate function, indices including （ 1 ） Half time liver excretion （Trx）, （2）Peak excretion（ CBD Tup）, （3）Gallbladder （GBVT）, （4） （GBT1/2...
Objective To research the changes of bile dynamics and plasma levels cholecystokinin (CCK) vasoactive intestinal peptide (VIP) in post-cholecystectomy patients. Methods Twenty-nine patients were selected as observation group, including 14 combined with duct dilatation 15 without dilatation. Another 17 healthy subjects enrolled control group. They assessed quantitative 99mTc-EHIDA hepatobiliary scintigraphy to determine dynamics. Plasma CCK VIP measured by enzyme-linked immunosorbent...