A5018820769- Antibiotics Pharmacokinetics and Efficacy
- Diet and metabolism studies
- Animal Nutrition and Physiology
- Advanced Drug Delivery Systems
- Veterinary Pharmacology and Anesthesia
- Analytical Methods in Pharmaceuticals
- Birth, Development, and Health
- Drug Transport and Resistance Mechanisms
- Clinical Nutrition and Gastroenterology
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Gut microbiota and health
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Pharmacological Effects and Toxicity Studies
- Veterinary medicine and infectious diseases
- Microfluidic and Capillary Electrophoresis Applications
- Galectins and Cancer Biology
- Steroid Chemistry and Biochemistry
- Synthesis and Biological Evaluation
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Polysaccharides and Plant Cell Walls
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
Nanjing Agricultural University
2007-2025
Qingdao University of Science and Technology
2024
Institute of Subtropical Agriculture
2022
Chinese Academy of Sciences
2022
A rapid, sensitive and reliable ultra–performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was developed validated for the simultaneous quantitation of pyrantel (PYR), praziquantel (PRA), febantel (FBT) its active metabolites, fenbendazole (FEN) oxfendazole (OXF) in dog plasma. Fenbendazole–D3 (FEN–D3) used as an internal standard (IS). The analytes IS were prepared using simple protein precipitation (PP) combined with liquid–liquid extraction (LLE). Chromatographic...
Intrauterine growth retardation (IUGR) is one of the major constraints in animal production. Our previous study showed that piglets with IUGR are associated abnormal bile acid (BA) metabolism. This explored whether dietary BA supplementation could improve performance and colonic development, function, microbiota, metabolites normal birth weight (NBW) piglets. A total 48 weaned (24 24 NBW) were allocated to four groups (12 per group): (i) NBW group, (ii) + (iii) (iv) group. Samples collected...
Intrauterine growth retardation (IUGR) results in intestinal dysfunction contributing to metabolic syndrome and lag of piglets. Bile acid (BA) presents various bioactivities, including regulation roles antioxidant, anti-inflammation, glucose lipid metabolism. Forty-eight weaned piglets were allocated four groups a 2 × factorial arrangement with the effects BA supplementation IUGR challenge. Twenty-four 24 normal birth weight (NBW) into two groups, respectively, control group fed basal diet,...
The objective of this study was to develop an injectable in situ forming gel system based on Poloxamer for sustained release Florfenicol (FFC). formulations were prepared containing certain amounts 407 (P407) and 188 (P188) alone or with hydroxylpropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (CMC‐Na), polyvinyl pyrrolidone (PVP) as polymer additives. optimal formulation chosen according vitro parameters (gelation temperature, gelation time, pH value, viscosity, release). Then...
The objective of this study was to develop an injectable in situ forming gel system based on Poloxamer for sustained release Astragalus polysaccharide (APS), thus achieved once or twice administration instead frequent dosing during long-term treatment. optimal formulation is 10 g APS, 18 poloxamer 407, 2 188, 0.15 CMC-Na, 0.85 sodium chloride 100 ml which had a preferable sol-gel transition temperature(T sol-gel) (34.1 ± 0.4°C), and good stability. In vitro studies, all formulations...
Piglets with intrauterine growth retardation (IUGR) have poor small intestinal morphology and function, resulting in impaired digestion absorption of nutrients lower performance. Bile acids (BA) are important regulating digestive enzyme activity, lipids, development, protecting the liver. The present study aimed to investigate effects dietary BA supplementation on plasma biochemical hormone indicators, microbial community piglets normal birth weight (NBW) IUGR. Weaned (24 IUGR 24 NBW) were...
Intrauterine growth retardation (IUGR) is associated with severely impaired nutrient metabolism and intestinal development of pigs. Our previous study found that IUGR altered microbiota metabolites in the colon. However, consequences on bile acid pigs remained unclear. The present aimed to investigate liver profile derivatives colon growing using targeted metabolomics. Furthermore, we determined correlations between colonic composition normal birth weight (NBW) at different stages were 7,...
Background: Flunixin is a Non-Steroidal Anti-Inflammatory Drug (NSAID), because it can effectively alleviate the organism of pyrexia, inflammation and pain, has been widely used in veterinary practice. In order to better study flunixin body's absorbed, distributed, metabolized excreted, our team developed UPLC-MS/MS method for determination swine plasma, urine feces. Methods: was extracted from sample by liquid-liquid extraction cleaned-up using mixed-mode Oasis MCX solid-phase column....
To reduce florfenicol ( FFC ) administration frequency in veterinary use, the drug was currently developed into situ forming gel. Twelve pigs were randomly divided two groups (six per group). A single i.m. dose of 40 mg/kg body weight (b.w.) given to pigs, group one gel, and conventional injection. High‐performance liquid chromatography HPLC used determine plasma concentrations. There significant differences P < 0.01) between gel injection, pharmacokinetic parameters MRT (mean retention...
The objective of this study was to evaluate the pharmacokinetic characteristics enrofloxacin (ENR) injectable in situ gel we developed dogs following a single intramuscular (i.m.) administration. Twelve healthy were randomly divided into two groups (six per group), then administrated 20 mg/kg body weight (b.w.) ENR and 5 b.w. conventional injection, respectively. High‐performance liquid chromatography (HPLC) used determine plasma concentrations. parameters injection are as follows: MRT (mean...
Abstract This study aimed to develop one novel meloxicam (MEL) oil suspension for sustained‐release and compare the pharmacokinetic characteristics of it with MEL conventional formulation in pigs after a single intramuscular administration. Six healthy were used by crossover design two periods withdrawal interval 14 days. Plasma concentrations measured ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS). Pharmacokinetic parameters calculated noncompartmental...
article or s.c.(subcutaneous) injection [1,2,27,31,35]Thereby, the recommended dosing regimen of ENR conventional was administrated a single 2.5 ~ 5 mg/kg b.w. per day twice day, meaning that course treatment needs multiple [40].Obviously, in clinical application caused lot inconvenience, for example, repeated stress response maybe worsen animals' illness result more disease, and drugs' action not sufficient when it peaks valleys, what's more, frequency administration spent great human,...
Abstract This study aimed to clarify the laws of glutamine tablets absorption, distribution, and metabolism in Beagles provide a basis for formulating dosing regimens. Twelve healthy were enrolled absolute bioavailability with crossover design . Glutamine (240 mg/kg b.w.) or sterile solution (60 administered. A method determination Beagles' plasma by UPLC‐MS/MS was established, high sensitivity, specificity, simplicity. Based on endogenous concentration, mean concentration four time points...
Glutamine is an amino acid that mainly used for the treatment of gastrointestinal diseases in clinic, but there a lack such medicine veterinary and its research dogs has never been seen. This study aimed to investigate pharmacokinetics single multiple administration glutamine (Gln) tablets Beagles. Twenty-four healthy Beagles were randomly selected pharmacokinetic dose low (120 mg/kg), medium (240 high (360 mg/kg) Gln tablets. After 7 days washout period, six group multiple-dose study, 240...