A5055970836- Carbohydrate Chemistry and Synthesis
- DNA and Nucleic Acid Chemistry
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Photosynthetic Processes and Mechanisms
- HIV/AIDS drug development and treatment
- Axial and Atropisomeric Chirality Synthesis
- Catalytic Alkyne Reactions
- Cancer Treatment and Pharmacology
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Galectins and Cancer Biology
- Synthesis and Characterization of Pyrroles
- Ubiquitin and proteasome pathways
- Oxidative Organic Chemistry Reactions
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Biochemical and Molecular Research
- Synthetic Organic Chemistry Methods
- Cancer-related molecular mechanisms research
- Algal biology and biofuel production
- Immune cells in cancer
- Metal complexes synthesis and properties
- RNA and protein synthesis mechanisms
Mitsubishi Tanabe Pharma Corporation
2017-2024
Tokyo Medical University
2024
Tokyo University of Science
2011
Total synthesis of Hirsutellone B has been achieved by a convergent synthetic strategy. This features direct construction the highly strained 13-membered macrocycle utilizing Ullmann-type reaction. To best our knowledge, this is first application macrocyclization an intramolecular reaction between aliphatic alcohol and aryl halide.
A transglycosylation reaction of 2'-amino-locked nucleic acid (LNA) from thymine (T) to other nucleobases adenine (A), guanine (G), and 5-methylcytosine (mC) has been developed. This proceeds in high yield with β-selectivity. The mild conditions enable the coexistence acid-labile protecting groups, including a 4,4'-dimethoxytrytyl (DMTr) group. 2'-Amino-LNAs bearing any nucleobase can now be easily synthesized.
Astrocytes are key components of the neurovascular unit. While we have recently identified Olig2+ astrocyte progenitors (ASPs) in developing mouse dentate gyrus (DG), their molecular signature remains incompletely characterized. Here demonstrate that ASPs predominantly express brain lipid-binding protein (BLBP), while only a small population them expresses gfap -GFP. These Olig2+/BLBP+ co-express transcription factors Sox3, Sox9 and proteoglycan NG2 but not Sox10, marker for oligodendrocyte...
Facile synthesis of GuNA (guanidine-bridged nucleic acid) phosphoramidites bearing thymine, adenine, guanine, and 5-methylcytosine nucleobases a robust method for the preparation GuNA-modified oligonucleotides are described.
Red alga contains four extrinsic proteins in photosystem II (PSII), which are PsbO, PsbV, PsbU, and PsbQ'. Except for the PsbQ', composition is same cyanobacterial PSII. Reconstitution analysis of PSII has shown that oxygen-evolving activity does not depend on presence Recently, structure red algal was elucidated. However, role PsbQ' remains unknown. In this study, function acceptor side analyzed PsbQ'-reconstituted by redox titration QA thermoluminescence. The potential positively shifted...
Objective: The objective of this study was to provide experimental chemists with useful guidance for proper choice a reasonable cyclization precursor in macrolactonization which there are several options disconnection analysis. Keywords: Neoantimycin, Prunustatin A, Macrocyclization, DFT calculation, MD simulation.
A deoxyribonuclease has been purified 570-fold from the 14-day-old chick embryos.The enzyme requires M&+ or Mn2+ ions for maximum activity.The optimum pH is 9.0 in 20 m~ Tris-HC1 buffer.Its isoelectric point 6.7.NaCl and N-ethylmaleimide strongly inhibit reaction.An apparent molecular weight of 45,000 determined by sedimentation a glycerol density gradient.The hydrolyzes denatured DNA 50 to 100 times more rapidly than duplex DNA.RNA synthetic polyribonucleotides are not substrate...
Abstract Diester, z.B. (IIIa)‐(IIIc), (Va) und (Vb) sowie (VI), werden dargestellt als Antitumormittel an Mäusen untersucht.