A5088616933- Veterinary Oncology Research
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Health, Education, and Aging
- Ear and Head Tumors
- Cutaneous Melanoma Detection and Management
- Cell Image Analysis Techniques
- Healthcare during COVID-19 Pandemic
- Animal Genetics and Reproduction
- Reproductive Health and Technologies
- Liver Disease Diagnosis and Treatment
- Education and Social Development in Ukraine
- Nonmelanoma Skin Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
Universidade Federal do Acre
2023
University of Wisconsin–Madison
2013
The aim of this paper is to discuss and update criteria that can guide the diagnosis, prognosis treatment canine feline mammary neoplasms. It was elaborated during IV Mammary Pathology Meeting: Diagnosis, Prognosis Treatment Canine Feline Neoplasia, held on April 29th 30th, 2019 in Belo Horizonte – MG, Brazil, sponsored by Laboratory Comparative Federal University Minas Gerais (UFMG), with support Brazilian Association Veterinary (ABPV) Oncology (ABROVET). Academics from several regions...
Spontaneous tumors in canines share significant genetic and histological similarities with human tumors, positioning them as valuable models to guide drug development. However, current translational studies have limited real world evidence cancer outcomes are dispersed across veterinary clinics genomic tests rarely performed on dogs. In this study, we aim expand the value of canine by systematically characterizing mutations their response targeted treatments. total, collect analyze survival...
Abstract Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose mutation profile are unknown (anal sac carcinoma and neuroendocrine carcinoma) or understudied (thyroid carcinoma, soft tissue sarcoma hepatocellular carcinoma). We discovered mutations in 50 well-established oncogenes suppressors, compared them...
Abstract Canine hemangiosarcoma (HSA) is an aggressive cancer of endothelial cells with short survival times. Understanding the genomic landscape HSA may aid in developing therapeutic strategies for dogs and also inform therapies rare human angiosarcoma. The objectives this study were to build a framework leveraging real‐world clinical data that could provide foundation precision medicine veterinary oncology, determine relationships between features canine splenic HSA. One hundred nine...
Abstract Transitional cell carcinoma (TCC), is the most common form of urinary bladder cancer in dogs and represents 2% all reported canine cancers. Canine TCC usually a high-grade invasive problems associated with include tract obstruction distant metastases more than 50% affected dogs. commonly located trigone region precluding complete surgical resection. Current treatment options for medical therapy, surgery or radiation. Mycobacterium Cell Wall Fraction (MCWF) biological immunomodulator...
Abstract Naturally occurring canine cancers have remarkable similarities to their human counterparts. In order determine whether these occur at the molecular level, we investigated hotspot mutations in a variety of spontaneously arising and found high concordance oncogenic drivers between both species. These findings suggest that canines may present powerful complementary model for preclinical investigations targeted cancer therapeutics. Through analysis 708 client-owned dogs from 96 breeds...
Abstract The widespread application of Poly-ADP ribose polymerase (PARP) inhibitors in anti-cancer therapy is constantly increasing their role as a treatment strategy across various neoplasms, the majority which are linked with BRCA deficiency. While most significant advantages observed cancers BRCA1/2 mutations, it evident that benefits extend beyond this specific group. Preclinical evidence encourages exploration PARP neoplasms demonstrating BRCAness or homologous recombination deficiency...
Abstract Osteosarcoma is the most common primary malignancy of bone in dogs and associated with poor long‐term outcomes due to its highly metastatic nature. A better understanding signalling pathways proteins involved osteosarcoma pathogenesis may aid improved through use targeted therapies. The Wnt5a protein, a ligand for non‐canonical Wnt pathway, implicated mediating aggressiveness cancer cell lines, including those human origin. Given close relationship between canine osteosarcoma, goal...
O melanoma cutâneo (MC) é uma forma incomum, mas frequentemente agressiva, de câncer pele devido à sua morbidade significativa e altas taxas mortalidade. Embora seja responsável por menos 5% todos os cânceres pele, a maioria das mortes relacionadas ao são melanoma. Descrever o perfil casos do em indivíduos com mais 50 anos no estado Alagoas, Brasil, entre 2018 2022. Trata-se um estudo transversal natureza descritiva. Foram utilizados dados maligno da coletados Departamento Informática...
O atual trabalho objetiva analisar e expôr a utilização de exames imagem na avaliação da esteatose hepática. Este estudo é uma revisão integrativa, que foi realizada partir pesquisa dos seguintes descritores em ciências saúde (DeCS): hepatic; steatosis; diagnostic; image. Destes, foram selecionados apenas artigos publicados no ano 2023, até data 05 julho, selecionando-se 17 artigos, onde 7 excluídos 10 analisados para confecção do trabalho. A por hepática possui grande relevância, tanto...
A endometriose é uma condição caracterizada pela presença de tecido endometrial fora do útero, formando lesões nos tecidos peritoneais, profundos e cistos ovarianos. Essas induzem resposta inflamatória crônica que resulta em dor dificuldades concepção. O presente estudo tem como objetivo conduzir análise abrangente da literatura sobre a infertilidade feminina decorrente endometriose, além descrever os aspectos epidemiológicos clínicos doença, bem sua relação possíveis contribuições para nas...
ABSTRACT Background Canine hemangiosarcoma (HSA) is an aggressive cancer of endothelial cells associated with short survival times. Understanding the genomic landscape HSA critical to developing more effective therapeutic strategies. Objectives To determine relationships between and clinical features including treatment outcome in canine splenic HSA. Animals 109 dogs primary treated by splenectomy that had tumor sequencing via FidoCure® Precision Medicine Platform targeted panel. Methods...
Abstract BRCA1 and BRCA2 (Breast cancer susceptibility gene 1 2) are tumor suppressor genes that maintain genomic stability by repairing damaged DNA. The proteins coded these involved in complexes activate the repair of double strand breaks (DSBs) initiate homologous recombination (HR). BRCA mutations common various forms human cancers, most notably breast cancer, previously described canine tumors. Tumors canines humans share many characteristics, including: inter-individual intra-tumoral...