A5103129083- Reproductive tract infections research
- Urinary Tract Infections Management
- Gut microbiota and health
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
Ragon Institute of MGH, MIT and Harvard
2023-2024
Mount Holyoke College
2022
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus-deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote microbiota dominance Lactobacillus iners instead of crispatus, which has more beneficial associations. Strategies to L. crispatus and inhibit are thus needed. We show that oleic acid (OA) similar long-chain fatty acids simultaneously enhance growth. These...
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus -deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote microbiota dominance iners instead of crispatus , which has more beneficial associations. Strategies to L. and inhibit are thus needed. We show that oleic acid (OA) similar long-chain fatty acids simultaneously enhance growth. These phenotypes require...
Non-coding small RNAs (sRNAs) are regulators of mRNA expression, and sRNA-mediated gene expression plays an important role in bacterial processes such as stress responses, metabolism, virulence, providing a promising field study to understand behavior. In the well-studied case E. coli, global RNA-binding proteins Hfq ProQ for supporting stability function sRNAs. However, many species that produce sRNAs do not encode either these proteins. This raises intriguing possibility there may be...