Kathryn Hoffman

ORCID: 0009-0005-6199-5755
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About
Contact & Profiles
Research Areas
  • Health and Well-being Studies
  • Family and Disability Support Research
  • Hibiscus Plant Research Studies
  • Neurogenetic and Muscular Disorders Research
  • Obesity, Physical Activity, Diet
  • Genetic Neurodegenerative Diseases
  • Palliative Care and End-of-Life Issues
  • Organizational Leadership and Management Strategies
  • Racial and Ethnic Identity Research
  • Biomedical and Engineering Education
  • Gender, Labor, and Family Dynamics
  • Migration, Health and Trauma
  • Chronic Disease Management Strategies
  • Coastal and Marine Management
  • Migration, Ethnicity, and Economy
  • Paraoxonase enzyme and polymorphisms
  • Muscle Physiology and Disorders
  • Environmental Education and Sustainability
  • Cynara cardunculus studies
  • Mitochondrial Function and Pathology
  • Interprofessional Education and Collaboration
  • Coral and Marine Ecosystems Studies
  • Physical Activity and Health
  • Health Promotion and Cardiovascular Prevention
  • Behavioral Health and Interventions

West Virginia University
2024

Indiana University of Pennsylvania
2024

Philadelphia College of Osteopathic Medicine
2023

Lurie Children's Hospital
2020

Medical University of Vienna
2019

University of Vienna
2018

Stanford University
2013

The Ohio State University
2012

The refugee crisis has resulted in massive waves of migration towards Europe. Besides sufficient and appropriate healthcare services, these vulnerable populations need kindness, respect, acceptance, empathy, attention to basic needs. Healthcare professionals ought have a respectful compassionate approach safeguard the dignity interests people they care for. overall aim European Refugees-Human Movement Advisory Network (EUR-HUMAN) project was provide good affordable, comprehensive,...

10.1186/s40639-018-0045-7 article EN cc-by Journal of Compassionate Health Care 2018-01-12

Physical activity (PA) is an important tool in health promotion, prevention, curation, and rehabilitation should be part of general practitioners (GP) consultations. For tailoring GP's service it to know the PA habits clients.Data from Austrian Health Interview Survey 2014 with 15,770 subjects were analyzed. The association between PA, measured Activity Questionnaire European Intervies (EHIS-PAQ) having visited a GP within last 4 weeks was examined different age groups (15-29, 30-64, 65+...

10.1007/s00508-019-1503-8 article EN cc-by Wiener klinische Wochenschrift 2019-05-10

Paraoxonase-1 (PON1) is a serum protein, the activity of which related to susceptibility cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, it possible lead molecule development catalytic bioscavenger OP pesticides nerve agents. Human PON1 expressed E. coli mostly found insoluble fraction, motivated engineering soluble variants, such as G2E6, with more than 50 mutations from huPON1. We examined effect on solubility,...

10.1155/2012/610937 article EN cc-by Journal of Lipids 2012-01-01

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial metabolic dysfunctions. SBMA caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing NAD+-dependent deacetylase, SIRT3, reduced oxidative stress death of cells modeling SBMA. However, diminished SIRT3 AR100Q mice failed to reduce acetylation target/antioxidant, SOD2, had no effect on increased total acetylated peptides quadriceps. Yet, overexpressing...

10.1016/j.isci.2023.107375 article EN cc-by-nc-nd iScience 2023-07-22

Platinum-resistant ovarian cancer (PROC) has many forms of treatment, the current most aggressive and effective treatment is Mirvetuximab Soravtansine (MIRV). MIRV a biomarker-driven antibody-drug conjugate composed antibody linked with non-cleavable linker to drug soravtansine, targeting folate receptor alpha (FRα). While date, one common side effects ocular events even blindness. Ocular occur in nearly 60 percent patients, The Mayo Clinic considers blindness "common effect." Off-target...

10.1016/j.jbc.2024.107007 article EN cc-by Journal of Biological Chemistry 2024-03-01
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