A5084750733- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Cardiac Ischemia and Reperfusion
- Shoulder Injury and Treatment
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Orthopedic Surgery and Rehabilitation
- Polyomavirus and related diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Prion Diseases and Protein Misfolding
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Peripheral Nerve Disorders
- Acute Kidney Injury Research
- Liver Disease Diagnosis and Treatment
University of Pittsburgh
2024
UPMC Hillman Cancer Center
2022
University of Pittsburgh Medical Center
2019-2022
Children's Hospital of Pittsburgh
2019
Significance Statement Proximal tubular epithelial cells, a primary site of injury in AKI, are rich mitochondria and peroxisomes, the two organelles that mediate fatty acid oxidation. Deletion Sirtuin 5 ( Sirt5 ) reverses posttranslational lysine acylation several enzymes involved The authors demonstrate mice lacking had significantly improved kidney function less tissue damage following either ischemia-induced or cisplatin-induced AKI compared with wild-type mice. These differences...
Merkel cell polyomavirus (MCV) is a small DNA tumor virus that persists in human skin and causes carcinoma (MCC) immunocompromised individuals. The multi-functional protein MCV T (sT) activates viral replication by stabilizing large (LT) promotes transformation through the LT stabilization domain (LTSD). Using MCVΔsT, mutant clone ablates sT, we investigated role of sT genome maintenance. was dispensable for initiation replication, but essential maintenance activation early late gene...
Carpal tunnel syndrome (CTS) is responsible for over 90 % of median nerve neuropathies. Though a clinical diagnosis, evaluation conduction via electrodiagnostic studies (EDX) and cross sectional area (CSA) through sonographic imaging provides supporting evidence insight into disease severity. The advent handheld ultrasound devices offers portable, cost-effective non-invasive method assessment, yet its accuracy compared to traditional cart-based has not been assessed in this setting.
The purpose of this study is to investigate the diagnostic accuracy a new noninvasive imaging technique, ultrasound-guided attenuation parameter (UGAP), in diagnosing hepatic steatosis. This single-center retrospective included 81 UGAP studies performed guide therapy between July 2022 and June 2023 at large academic medical center. Patients with either liver biopsy or Magnetic resonance-based proton-density fat fraction (MRI-PDFF) within 12 months US-UGAP imaging, irrespective order, were...