A5088382406- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Hemophilia Treatment and Research
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Cancer-related gene regulation
- Medical Imaging Techniques and Applications
- Radioactive element chemistry and processing
- Minimally Invasive Surgical Techniques
- Surgical Simulation and Training
- Protein purification and stability
- Heart Failure Treatment and Management
- Histone Deacetylase Inhibitors Research
- Uterine Myomas and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Estrogen and related hormone effects
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
Bayer (Germany)
2011-2024
Committee on Publication Ethics
2020
Background The presence of gadolinium traces in the skin after administration gadolinium-based contrast agents (GBCAs) raised safety concerns regarding a potential association with small fiber neuropathy (SFN). Purpose To investigate signs SFN rat foot pads by quantification intraepidermal nerve density (IENFD) multiple GBCA administrations and to evaluate concentration, chemical species, clearance. Materials Methods Fifty rats received eight intravenous injections either gadodiamide,...
Discrepancies in the measurement of modified factor VIII (FVIII) products have been recognized, highlighting need for adjustments clinical laboratory practices to ensure effective monitoring patients treated with these products, particularly using one-stage (activated partial thromboplastin time [aPTT]) assay.To assess ability laboratories measure activity BAY 94-9027, a PEGylated extended half-life FVIII product, routine (predominantly one-stage) assays METHODS: Blinded samples...
Background Approved therapies for pulmonary arterial hypertension can induce oxygen desaturation when administered to patients with secondary forms of (PH), probably due an increase in ventilation/perfusion mismatch. Thus, so far these treatments have largely failed PH. Methods We established animal model heterogeneous lung ventilation evaluate the potential mechanistically distinct vasoactive drugs launched or currently clinical development treatment Single-lung was induced five groups (N =...
Aberrant methylation of promoter regions involved in silencing tumor suppressor genes is a key feature many human cancers including melanoma. These DNA events occur early cancer development, increase with progression, and may therefore serve as biomarkers for the detection staging cancer. In our study, we used an epigenomic reactivation screening approach Combined Bisulfite Restriction Analyses (COBRA) assays to identify novel markers late-stage Two xenograft melanoma models have been...
Endometriosis is a chronic, estrogen-dependent disease characterized by the presence of ectopic endometrium either in pelvic cavity (endometriosis externa) or within uterus interna, adenomyosis). Key symptoms are pain, dysmenorrhea and infertility. Established rodent animal models used for drug research endometriosis have certain limitations. Since rodents do not menstruate, they cannot develop externa spontaneously, but suffer from interna. There growing evidence that human interna...
Objective The gadolinium (Gd) concentrations in the cerebellum and cerebrum of rabbits elimination kinetics were compared after repeated injection macrocyclic Gd-based contrast agents (GBCAs) gadobutrol gadoteridol. Materials Methods Male white New Zealand (2.4–3.1 kg) 2 study groups (n = 21 each) received 3 injections either or gadoteridol at 0.9 mmol Gd/kg within 5 days (total dose, 2.7 Gd/kg). Animals one control group 9) saline (1.8 mL/kg). After 2, 6, 12 weeks, 7 animals from each...
Abstract Endometriosis in an estrogen‐dependent disease that is characterized by the presence of endometrial tissue outside uterine cavity leading to pain and infertility many affected women. Highly efficient treatment options which create a hypo‐estrogenic environment can cause side effects such as hot flushes bone mass loss are not favorable for premenopausal Previous work has demonstrated increased local or systemic prolactin seems be involved pathogenesis endometriosis. Here we examined...